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Pharmaceuticals 2015, 8(4), 848-864; doi:10.3390/ph8040848

Marine Non-Glycosaminoglycan Sulfated Glycans as Potential Pharmaceuticals

Program of Glycobiology, Institute of Medical Biochemistry Leopoldo de Meis, University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941-913, Brazil
Academic Editors: Madalena M. M. Pinto, Maria Emília de Sousa and Marta Correia da Silva
Received: 9 October 2015 / Revised: 30 November 2015 / Accepted: 8 December 2015 / Published: 10 December 2015
(This article belongs to the Special Issue Grand Celebration: 100th Anniversary of the Discovery of Heparin)
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Sulfated fucans (SFs) and sulfated galactans (SGs) are currently the marine non-glycosaminoglycan (GAG) sulfated glycans most studied in glycomics. These compounds exhibit therapeutic effects in several pathophysiological systems such as blood coagulation, thrombosis, neovascularization, cancer, inflammation, and microbial infections. As analogs of the largely employed GAGs and due to some limitations of the GAG-based therapies, SFs and SGs comprise new carbohydrate-based therapeutics available for clinical studies. Here, the principal structural features and the major mechanisms of action of the SFs and SGs in the above-mentioned pathophysiological systems are presented. Discussion is also given on the current challenges and the future perspectives in drug development of these marine glycans. View Full-Text
Keywords: angiogenesis; cancer; coagulation; inflammation; marine glycans; microbial infection; sulfated fucans; sulfated galactans; thrombosis angiogenesis; cancer; coagulation; inflammation; marine glycans; microbial infection; sulfated fucans; sulfated galactans; thrombosis

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Pomin, V.H. Marine Non-Glycosaminoglycan Sulfated Glycans as Potential Pharmaceuticals. Pharmaceuticals 2015, 8, 848-864.

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