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Pharmaceuticals 2014, 7(1), 29-45; doi:10.3390/ph7010029
Review

Are AMPA Receptor Positive Allosteric Modulators Potential Pharmacotherapeutics for Addiction?

1,*  and 1,2
Received: 28 October 2013 / Revised: 13 December 2013 / Accepted: 24 December 2013 / Published: 30 December 2013
(This article belongs to the Special Issue Allosteric Modulators)
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Abstract

Positive allosteric modulators (PAMs) of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are a diverse class of compounds that increase fast excitatory transmission in the brain. AMPA PAMs have been shown to facilitate long-term potentiation, strengthen communication between various cortical and subcortical regions, and some of these compounds increase the production and release of brain-derived neurotrophic factor (BDNF) in an activity-dependent manner. Through these mechanisms, AMPA PAMs have shown promise as broad spectrum pharmacotherapeutics in preclinical and clinical studies for various neurodegenerative and psychiatric disorders. In recent years, a small collection of preclinical animal studies has also shown that AMPA PAMs may have potential as pharmacotherapeutic adjuncts to extinction-based or cue-exposure therapies for the treatment of drug addiction. The present paper will review this preclinical literature, discuss novel data collected in our laboratory, and recommend future research directions for the possible development of AMPA PAMs as anti-addiction medications.
Keywords: AMPA PAMs; positive allosteric modulators; extinction; addiction AMPA PAMs; positive allosteric modulators; extinction; addiction
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Watterson, L.R.; Olive, M.F. Are AMPA Receptor Positive Allosteric Modulators Potential Pharmacotherapeutics for Addiction? Pharmaceuticals 2014, 7, 29-45.

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