Next Article in Journal
Nanoparticle-Based Delivery of RNAi Therapeutics: Progress and Challenges
Next Article in Special Issue
In Vitro Assessment of Clevidipine Using the Profilin1 Hypertensive Mouse Model
Previous Article in Journal
A Potent (R)-alpha-bis-lipoyl Derivative Containing 8-Hydroxyquinoline Scaffold: Synthesis and Biological Evaluation of Its Neuroprotective Capabilities in SH-SY5Y Human Neuroblastoma Cells
Pharmaceuticals 2013, 6(1), 70-84; doi:10.3390/ph6010070
Review

Clevidipine for Perioperative Blood Pressure Control in Infants and Children

1,* , 2
 and 2
Received: 11 December 2012 / Revised: 28 December 2012 / Accepted: 11 January 2013 / Published: 15 January 2013
(This article belongs to the Special Issue Calcium Antagonists)
View Full-Text   |   Download PDF [184 KB, uploaded 15 January 2013]

Abstract

Various pharmacologic agents have been used for perioperative BP control in pediatric patients, including sodium nitroprusside, nitroglycerin, β-adrenergic antagonists, fenoldopam, and calcium channel antagonists. Of the calcium antagonists, the majority of the clinical experience remains with the dihydropyridine nicardipine. Clevidipine is a short-acting, intravenous calcium channel antagonist of the dihydropyridine class. It undergoes rapid metabolism by non-specific blood and tissue esterases with a half-life of less than 1 minute. As a dihydropyridine, its cellular and end-organ effects parallel those of nicardipine. The clevidipine trials in the adult population have demonstrated efficacy in rapidly controlling BP in various clinical scenarios with a favorable adverse effect profile similar to nicardipine. Data from large clinical trials regarding the safety and efficacy of clevidipine in children is lacking. This manuscript aims to review the commonly used pharmacologic agents for perioperative BP control in children, discuss the role of calcium channel antagonists such as nicardipine, and outline the preliminary data regarding clevidipine in the pediatric population.
Keywords: clevidipine; pediatric hypertension; acute hypertension clevidipine; pediatric hypertension; acute hypertension
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Tobias, J.D.; Tulman, D.B.; Bergese, S.D. Clevidipine for Perioperative Blood Pressure Control in Infants and Children. Pharmaceuticals 2013, 6, 70-84.

View more citation formats

Related Articles

Article Metrics

Comments

Citing Articles

[Return to top]
Pharmaceuticals EISSN 1424-8247 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert