Next Article in Journal
Clevidipine for Perioperative Blood Pressure Control in Infants and Children
Next Article in Special Issue
The Use of Central Nervous System Active Drugs During Pregnancy
Previous Article in Journal
The Potential Role of Cell Penetrating Peptides in the Intracellular Delivery of Proteins for Therapy of Erythroid Related Disorders
Pharmaceuticals 2013, 6(1), 54-69; doi:10.3390/ph6010054
Article

A Potent (R)-alpha-bis-lipoyl Derivative Containing 8-Hydroxyquinoline Scaffold: Synthesis and Biological Evaluation of Its Neuroprotective Capabilities in SH-SY5Y Human Neuroblastoma Cells

1,* , 1, 1, 1, 2,3, 2,3, 2,3 and 1
Received: 6 December 2012 / Revised: 18 December 2012 / Accepted: 31 December 2012 / Published: 7 January 2013
(This article belongs to the Special Issue CNS-Drugs and Therapy)
View Full-Text   |   Download PDF [887 KB, 8 January 2013; original version 7 January 2013]   |   Browse Figures

Abstract

A novel bis-lipoyl derivative containing 8-hydroxyquinoline scaffold (LA-HQ-LA, 5) was synthesized as a new multifunctional drug candidate with antioxidant, chelant, and neuroprotective properties for the treatment of neurodegenerative diseases. We have investigated the potential effectiveness of LA-HQ-LA against the cytotoxicity induced by 6-OHDA and H2O2 on human neuroblastoma SH-SY5Y cell line. Our outcomes showed that LA-HQ-LA resulted in significant neuroprotective and antioxidant effects against H2O2- and 6-OHDA-induced neurotoxicity in human neuroblastoma SH-SY5Y cells, as assessed by MTT assay. In particular, it showed potent neuroprotective effects against 6-OHDA in RA/PMA differentiated cells at all the tested concentrations.
Keywords: (R)-alpha-lipoic acid; 8-hydroxyquinoline; neuroprotective agent; antioxidants; neurodegenerative diseases (R)-alpha-lipoic acid; 8-hydroxyquinoline; neuroprotective agent; antioxidants; neurodegenerative diseases
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Cacciatore, I.; Fornasari, E.; Baldassarre, L.; Cornacchia, C.; Fulle, S.; Di Filippo, E.S.; Pietrangelo, T.; Pinnen, F. A Potent (R)-alpha-bis-lipoyl Derivative Containing 8-Hydroxyquinoline Scaffold: Synthesis and Biological Evaluation of Its Neuroprotective Capabilities in SH-SY5Y Human Neuroblastoma Cells. Pharmaceuticals 2013, 6, 54-69.

View more citation formats

Related Articles

Article Metrics

Comments

Citing Articles

[Return to top]
Pharmaceuticals EISSN 1424-8247 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert