Special Issue "Calcium Antagonists"


A special issue of Pharmaceuticals (ISSN 1424-8247).

Deadline for manuscript submissions: closed (28 February 2013)

Special Issue Editors

Guest Editor
Prof. Dr. Toni Schneider
Institute of Neurophysiology, Medical Faculty, University of Cologne, 39 50931 Köln, Germany
Website: http://www.uni-koeln.de/med-fak/physiologie/np/np_en/schneider.htm
Interests: channelopathies; “pharmacoresistant” (R-type) calcium channel
Guest Editor
Dr. Gary J. Stephens
School of Pharmacy, University of Reading, Whiteknights, PO Box 228, Reading RG6 6AJ, UK
Website: http://www.reading.ac.uk/pharmacy/about/staff/g-j-stephens.aspx
Interests: SUMOylation of calcium channels; cannabinoid CB1 receptor signalling in the CNS; molecular determinants for G protein inhibition of calcium channels

Special Issue Information

Dear Colleagues,

"Calcium antagonism“ was initially developed as a novel pharmacodynamic concept, which prevented cytosolic Ca2+ increase in cardiac tissue. It was initially developed by the A. Fleckenstein group in Freiburg [1]. The therapeutic consequences are widespread and are initiated by the inhibition of the transmembrane Ca2+ flux. Such an antagonism normalizes hyperkinetic cardiac disorders, suppresses arterial and arteriolar spasms, relieves systemic arterial hypertension and may stop cardiac arrhythmia.

Initially, the targets of classical Ca2+ channel antagonists were only named as “receptors” as Ca2+ channels proteins underlying these responses remained unidentified. Subsequently, ten different genes were successfully cloned for the voltage-gated ion conducting pore, and an increasing number of auxiliary or interacting subunits were identified.
Ca2+ channel antagonists were instrumental in the determination of function for each of the voltage-gated Ca2+ channels. In the genomic age, the development of mouse models with gene inactivated subunits has significantly aid the deduction of their function. The molecular interaction of Ca2+ channel subunits was and will be specified by high resolution crystallography. We now also have some information about the Ca2+ channel proteome. Knowing the molecular minimal structure for interactions will also accelerate the development of more selective Ca2+ channel antagonists. Novel powerful compounds are needed, because some Ca2+ channels are still lacking selective antagonism including the “resistant” (R-) type, and the T-type voltage-gated Ca2+ channels.

Reference List:
1. Fleckenstein A. Historical overview. The calcium channel of the heart. Ann. N.Y. Acad. Sci. 1988, 522, 1-15.

Prof. Dr. Toni Schneider
Dr. Gary J. Stephens
Guest Editors


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  • voltage-gated calcium channels
  • dihydropyridines
  • phenylalkylamines
  • benzothiazepines
  • peptide toxins
  • cloning
  • crystallization

Published Papers (5 papers)

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Displaying article 1-5
p. 788-812
by , ,  and
Pharmaceuticals 2013, 6(7), 788-812; doi:10.3390/ph6070788
Received: 29 March 2013 / Revised: 6 June 2013 / Accepted: 6 June 2013 / Published: 26 June 2013
Show/Hide Abstract | Cited by 3 | PDF Full-text (260 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Calcium Antagonists)
p. 777-787
by , ,  and
Pharmaceuticals 2013, 6(6), 777-787; doi:10.3390/ph6060777
Received: 25 February 2013 / Revised: 13 May 2013 / Accepted: 14 May 2013 / Published: 29 May 2013
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(This article belongs to the Special Issue Calcium Antagonists)
p. 689-699
by  and
Pharmaceuticals 2013, 6(6), 689-699; doi:10.3390/ph6060689
Received: 4 March 2013 / Revised: 15 April 2013 / Accepted: 2 May 2013 / Published: 23 May 2013
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(This article belongs to the Special Issue Calcium Antagonists)
p. 623-633
by , , , , ,  and
Pharmaceuticals 2013, 6(5), 623-633; doi:10.3390/ph6050623
Received: 21 December 2012 / Accepted: 19 April 2013 / Published: 29 April 2013
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(This article belongs to the Special Issue Calcium Antagonists)
p. 70-84
by ,  and
Pharmaceuticals 2013, 6(1), 70-84; doi:10.3390/ph6010070
Received: 11 December 2012 / Revised: 28 December 2012 / Accepted: 11 January 2013 / Published: 15 January 2013
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Last update: 9 October 2012

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