Molecular Dynamics Simulations of Hsp90 with an Eye to Inhibitor Design
AbstractProteins carry out their functions through interactions with different partners. Dynamic conformational switching among different structural sub-states favors the adaptation to the shapes of the different partners. Such conformational changes can be determined by diverse biochemical factors, such as ligand-binding. Atomic level investigations of the mechanisms that underlie functional dynamics may provide new opportunities for the discovery of leads that target disease-related proteins. In this review, we report our views and approaches on the development of novel and accurate physical-chemistry-based models for the characterization of the salient aspects of the ligand-regulated dynamics of Hsp90, and on the exploitation of such new knowledge for the rational discovery of inhibitors of the chaperone.
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Moroni, E.; Morra, G.; Colombo, G. Molecular Dynamics Simulations of Hsp90 with an Eye to Inhibitor Design. Pharmaceuticals 2012, 5, 944-962.
Moroni E, Morra G, Colombo G. Molecular Dynamics Simulations of Hsp90 with an Eye to Inhibitor Design. Pharmaceuticals. 2012; 5(9):944-962.Chicago/Turabian Style
Moroni, Elisabetta; Morra, Giulia; Colombo, Giorgio. 2012. "Molecular Dynamics Simulations of Hsp90 with an Eye to Inhibitor Design." Pharmaceuticals 5, no. 9: 944-962.