Next Article in Journal
Drug Induced Hypersensitivity and the HLA Complex
Next Article in Special Issue
Bioequivalence of Two Intravenous Artesunate Products with Its Active Metabolite Following Single and Multiple Injections
Previous Article in Journal
GPCR Conformations: Implications for Rational Drug Design
Previous Article in Special Issue
Artemisinin-Naphthoquine Combination (ARCO®): An Overview of the Progress
Article Menu

Export Article

Open AccessReview
Pharmaceuticals 2011, 4(1), 44-68; doi:10.3390/ph4010044

Blocking Plasmodium falciparum Malaria Transmission with Drugs: The Gametocytocidal and Sporontocidal Properties of Current and Prospective Antimalarials

Department of Natural and Applied Sciences, Bentley University, Waltham, MA 02452, USA
Received: 30 November 2010 / Revised: 14 December 2010 / Accepted: 21 December 2010 / Published: 23 December 2010
(This article belongs to the Special Issue New Antimalarial Drugs)
View Full-Text   |   Download PDF [177 KB, uploaded 23 December 2010]


Drugs that kill or inhibit the sexual stages of Plasmodium could potentially amplify or synergize the impact of other interventions by blocking transmission to mosquitoes. Primaquine and other 8-aminoquinolines have long offered such potential, but safety and other concerns have limited their use. Although transmission-blocking properties are not often a priority of drug discovery efforts, a number of interesting gametocytocidal and/or sporontocidal drug candidates have emerged in recent years. Some still bear significant technical and safety concerns, while others have passed clinical trials and are on the verge of entering the antimalarial armamentarium. Recent advances in our knowledge of gametocyte differentiation, gametogenesis and sporogony have also led to the identification of a large array of potential new targets for drugs that might interfere with malaria transmission. This review examines the properties of existing and prospective drugs, mechanisms of action, counter-indications and their potential role in regional malaria elimination efforts.
Keywords: Plasmodium; gametocyte; sporogony; antimalarials; transmission-blocking Plasmodium; gametocyte; sporogony; antimalarials; transmission-blocking
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Kiszewski, A.E. Blocking Plasmodium falciparum Malaria Transmission with Drugs: The Gametocytocidal and Sporontocidal Properties of Current and Prospective Antimalarials. Pharmaceuticals 2011, 4, 44-68.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Pharmaceuticals EISSN 1424-8247 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top