Pharmaceuticals 2011, 4(1), 7-43; doi:10.3390/ph4010007
Review

GPCR Conformations: Implications for Rational Drug Design

Abby L. Parrill 1,* email and Debra L. Bautista 2 email
1 Department of Chemistry, The University of Memphis, Memphis, TN 38152, USA 2 Christian Brothers High School, 5900 Walnut Grove Road, Memphis, TN 38120, USA
* Author to whom correspondence should be addressed.
Received: 24 November 2010; in revised form: 20 December 2010 / Accepted: 21 December 2010 / Published: 23 December 2010
(This article belongs to the Special Issue GPCR Based Drug Discovery)
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Abstract: G protein-coupled receptors (GPCRs) comprise a large class of transmembrane proteins that play critical roles in both normal physiology and pathophysiology. These critical roles offer targets for therapeutic intervention, as exemplified by the substantial fraction of current pharmaceutical agents that target members of this family. Tremendous contributions to our understanding of GPCR structure and dynamics have come from both indirect and direct structural characterization techniques. Key features of GPCR conformations derived from both types of characterization techniques are reviewed.
Keywords: G protein-coupled receptor; GPCR; structure; crystallography; NMR; modeling

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Cite This Article

MDPI and ACS Style

Parrill, A.L.; Bautista, D.L. GPCR Conformations: Implications for Rational Drug Design. Pharmaceuticals 2011, 4, 7-43.

AMA Style

Parrill AL, Bautista DL. GPCR Conformations: Implications for Rational Drug Design. Pharmaceuticals. 2011; 4(1):7-43.

Chicago/Turabian Style

Parrill, Abby L.; Bautista, Debra L. 2011. "GPCR Conformations: Implications for Rational Drug Design." Pharmaceuticals 4, no. 1: 7-43.

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