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GPCR Conformations: Implications for Rational Drug Design
Department of Chemistry, The University of Memphis, Memphis, TN 38152, USA
Christian Brothers High School, 5900 Walnut Grove Road, Memphis, TN 38120, USA
* Author to whom correspondence should be addressed.
Received: 24 November 2010; in revised form: 20 December 2010 / Accepted: 21 December 2010 / Published: 23 December 2010
Abstract: G protein-coupled receptors (GPCRs) comprise a large class of transmembrane proteins that play critical roles in both normal physiology and pathophysiology. These critical roles offer targets for therapeutic intervention, as exemplified by the substantial fraction of current pharmaceutical agents that target members of this family. Tremendous contributions to our understanding of GPCR structure and dynamics have come from both indirect and direct structural characterization techniques. Key features of GPCR conformations derived from both types of characterization techniques are reviewed.
Keywords: G protein-coupled receptor; GPCR; structure; crystallography; NMR; modeling
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MDPI and ACS Style
Parrill, A.L.; Bautista, D.L. GPCR Conformations: Implications for Rational Drug Design. Pharmaceuticals 2011, 4, 7-43.
Parrill AL, Bautista DL. GPCR Conformations: Implications for Rational Drug Design. Pharmaceuticals. 2011; 4(1):7-43.
Parrill, Abby L.; Bautista, Debra L. 2011. "GPCR Conformations: Implications for Rational Drug Design." Pharmaceuticals 4, no. 1: 7-43.