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Pharmaceuticals 2010, 3(9), 2884-2899; doi:10.3390/ph3092884

Antiepileptic Drug Discovery and Development: What Have We Learned and Where Are We Going?

Icagen, Inc., 4222 Emperor Blvd, Durham, NC 27703, USA
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Received: 19 August 2010 / Revised: 25 August 2010 / Accepted: 1 September 2010 / Published: 1 September 2010
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Abstract

Current marketed antiepileptic drugs (AEDs) consist of a variety of structural classes with different mechanisms of action. These agents typically have non-overlapping efficacy and side-effect profiles presenting multiple treatment options for the patient population. However, approximately 30% of seizure sufferers fail to respond to current therapies often because poorly tolerated side-effects limit adequate dosing. The scope of this review is to summarize selected advances in 2nd and 3rd generation AEDs as well as compounds in development with novel mechanisms of action.
Keywords: epilepsy; antiepileptic; AED; seizure; anticonvulsant epilepsy; antiepileptic; AED; seizure; anticonvulsant
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Gerlach, A.C.; Krajewski, J.L. Antiepileptic Drug Discovery and Development: What Have We Learned and Where Are We Going? Pharmaceuticals 2010, 3, 2884-2899.

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