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Dendritic Cell Regulation by Cannabinoid-Based Drugs
Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, 141 86, Stockholm, Sweden
* Author to whom correspondence should be addressed.
Received: 2 July 2010; in revised form: 11 August 2010 / Accepted: 20 August 2010 / Published: 23 August 2010
Abstract: Cannabinoid pharmacology has made important advances in recent years after the cannabinoid system was discovered. Studies in experimental models and in humans have produced promising results using cannabinoid-based drugs for the treatment of obesity and cancer, as well as neuroinflammatory and chronic inflammatory diseases. Moreover, as we discuss here, additional studies also indicates that these drugs have immunosuppressive and anti-inflammatory properties including modulation of immune cell function. Thus, manipulation of the endocannabinoid system in vivo may provide novel therapeutic strategies against inflammatory disorders. At least two types of cannabinoid receptors, cannabinoid 1 and cannabinoid 2 receptors are expressed on immune cells such as dendritic cells (DC). Dendritic cells are recognized for their critical role in initiating and maintaining immune responses. Therefore, DC are potential targets for cannabinoid-mediated modulation. Here, we review the effects of cannabinoids on DC and provide some perspective concerning the therapeutic potential of cannabinoids for the treatment of human diseases involving aberrant inflammatory processes.
Keywords: Cannabinoids; dendritic cells; inflammation; immunomodulation; KV-channels
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MDPI and ACS Style
Svensson, M.; Chen, P.; Hammarfjord, O. Dendritic Cell Regulation by Cannabinoid-Based Drugs. Pharmaceuticals 2010, 3, 2733-2750.
Svensson M, Chen P, Hammarfjord O. Dendritic Cell Regulation by Cannabinoid-Based Drugs. Pharmaceuticals. 2010; 3(8):2733-2750.
Svensson, Mattias; Chen, Puran; Hammarfjord, Oscar. 2010. "Dendritic Cell Regulation by Cannabinoid-Based Drugs." Pharmaceuticals 3, no. 8: 2733-2750.