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Pharmaceuticals 2010, 3(8), 2387-2397; doi:10.3390/ph3082387

Measurement of Neuropsychiatric Symptoms in Clinical Trials Targeting Alzheimer's Disease and Related Disorders

1
Centre Mémoire de Ressources et de Recherche/Hôpital de Cimiez, 4 av Reine Victoria, 06000 Nice, France
2
Centre d’Innovation et d’Usage en Santé (CIU-S) / Hôpital de Cimiez, 4 av Reine Victoria, 06000 Nice, France
*
Author to whom correspondence should be addressed.
Received: 2 June 2010 / Revised: 21 June 2010 / Accepted: 20 July 2010 / Published: 26 July 2010
(This article belongs to the Special Issue Alzheimer's Disease Drugs)
View Full-Text   |   Download PDF [182 KB, uploaded 26 July 2010]

Abstract

Behavioral and psychological symptoms (BPSD) are now known to be frequently associated to cognitive and functional decline in Alzheimer‘s disease and related disorders. They are present since the early stages of the disease and have negative impact on the disease process. BPSD assessment is crucial in clinical practice and also in future clinical trials targeting disease-modifying therapies for dementia. In this article, we will first review current assessment tools for BPSD, mainly global and domain-specific scales, and new assessment methods, currently available or in development, including new scales, diagnostic criteria and new technologies such as ambulatory actigraphy.
Keywords: neuropsychiatric symptoms; assessment tools; Alzheimer’s disease; clinical trials; actigraphy neuropsychiatric symptoms; assessment tools; Alzheimer’s disease; clinical trials; actigraphy
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

David, R.; Mulin, E.; Mallea, P.; Robert, P.H. Measurement of Neuropsychiatric Symptoms in Clinical Trials Targeting Alzheimer's Disease and Related Disorders. Pharmaceuticals 2010, 3, 2387-2397.

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