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Pharmaceuticals 2010, 3(6), 1729-1738; doi:10.3390/ph3061729
Review

The Role of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) in the Management of the Post-Embolization Symptoms after Uterine Artery Embolization

1,2,*  and 1,3
1 Saint Louis Hospital, Interventional Radiology / Rua Luz Soriano, 182, Lisbon 1200-249, Portugal 2 Departamento de Anatomia, Faculdade de Ciências Médicas (FCM), Universidade Nova de Lisboa, 1169-056, Lisboa, Portugal 3 Departamento de Radiologia, Faculdade de Ciências Médicas (FCM), Universidade Nova de Lisboa, 1169-056, Lisboa, Portugal
* Author to whom correspondence should be addressed.
Received: 23 March 2010 / Revised: 30 April 2010 / Accepted: 24 May 2010 / Published: 26 May 2010
(This article belongs to the collection Non-Steroidal Anti-Inflammatory Drugs)
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Abstract

Uterine artery embolization (UAE) is usually a very painful procedure. Although pain after the procedure can occur as a single symptom, it usually is associated with other symptoms such as nausea, vomiting, pelvic pain, general malaise, fever and leukocytosis that characterize the post-embolization syndrome. Management of the post-embolization symptoms and of pain in particular, is paramount if UAE is to be performed as an outpatient procedure. Different protocols have used analgesic and/or anti-inflammatory agents to control these symptoms. Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used in association with analgesic drugs to control post-embolization symptoms. In our institution the patients start oral medication with NSAIDs the day before the procedure and continue it during and after UAE. We also mix NSAIDs with the embolizing particles. This enables a reduction in the inflammation present in the uterine fibroids and helps controlling the pain. The purpose of this paper is to review the importance of NSAIDs in the management of the post-embolization symptoms. We describe the protocol that we use in our institution that enables us to perform the procedure on an outpatient basis with same day discharge and good control of the post-embolization symptoms with oral NSAIDs and analgesics.
Keywords: uterine artery embolization; post-embolization syndrome; nonsteroidal anti-inflammatory drugs uterine artery embolization; post-embolization syndrome; nonsteroidal anti-inflammatory drugs
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Bilhim, T.; Pisco, J.M. The Role of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) in the Management of the Post-Embolization Symptoms after Uterine Artery Embolization. Pharmaceuticals 2010, 3, 1729-1738.

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