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Pharmaceuticals 2010, 3(6), 1812-1841; doi:10.3390/ph3061812
Review

Non-Steroidal Anti-Inflammatory Drugs in Alzheimer's Disease and Parkinson's Disease: Reconsidering the Role of Neuroinflammation

* , , , , , ,  and
Received: 8 April 2010 / Revised: 10 May 2010 / Accepted: 2 June 2010 / Published: 2 June 2010
(This article belongs to the collection Non-Steroidal Anti-Inflammatory Drugs)
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Abstract

Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common neurodegenerative diseases with age as the greatest risk factor. As the general population experiences extended life span, preparation for the prevention and treatment of these and other age-associated neurological diseases are warranted. Since epidemiological studies suggested that non-steroidal anti-inflammatory drug (NSAID) use decreased risk for AD and PD, increasing attention has been devoted to understanding the costs and benefits of the innate neuroinflammatory response to functional recovery following pathology onset. This review will provide a general overview on the role of neuroinflammation in these neurodegenerative diseases and an update on NSAID treatment in recent experimental animal models, epidemiological analyses, and clinical trials.
Keywords: Non-steroidal anti-inflammatory drugs; Alzheimer's disease; Parkinson's disease; cyclooxygenase; neuroinflammation Non-steroidal anti-inflammatory drugs; Alzheimer's disease; Parkinson's disease; cyclooxygenase; neuroinflammation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Moore, A.H.; Bigbee, M.J.; Boynton, G.E.; Wakeham, C.M.; Rosenheim, H.M.; Staral, C.J.; Morrissey, J.L.; Hund, A.K. Non-Steroidal Anti-Inflammatory Drugs in Alzheimer's Disease and Parkinson's Disease: Reconsidering the Role of Neuroinflammation. Pharmaceuticals 2010, 3, 1812-1841.

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