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• Moore, A
• Bigbee, M
• Boynton, G
• Wakeham, C
• Rosenheim, H
• Staral, C
• Morrissey, J
• Hund, A
• [+] on Google Scholar
• Moore, A
• Bigbee, M
• Boynton, G
• Wakeham, C
• Rosenheim, H
• Staral, C
• Morrissey, J
• Hund, A
• [+] on PubMed
• Moore, A
• Bigbee, M
• Boynton, G
• Wakeham, C
• Rosenheim, H
• Staral, C
• Morrissey, J
• Hund, A

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Pharmaceuticals 2010, 3(6), 1812-1841; doi:10.3390/ph3061812

Review

Non-Steroidal Anti-Inflammatory Drugs in Alzheimer's Disease and Parkinson's Disease: Reconsidering the Role of Neuroinflammation

Amy H. Moore* , Matthew J. Bigbee, Grace E. Boynton, Colin M. Wakeham, Hilary M. Rosenheim, Christopher J. Staral, James L. Morrissey and Amanda K. Hund

Department of Biology, Carleton College, one north college street, Northfield, MN 55057, USA

* Author to whom correspondence should be addressed.

Received: 8 April 2010; in revised form: 10 May 2010 / Accepted: 2 June 2010 / Published: 2 June 2010

(This article belongs to the Special Issue Non-Steroidal Anti-Inflammatory Drugs)

Download PDF Full-Text [867 KB, uploaded 2 June 2010 13:46 CEST]

Abstract: Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common neurodegenerative diseases with age as the greatest risk factor. As the general population experiences extended life span, preparation for the prevention and treatment of these and other age-associated neurological diseases are warranted. Since epidemiological studies suggested that non-steroidal anti-inflammatory drug (NSAID) use decreased risk for AD and PD, increasing attention has been devoted to understanding the costs and benefits of the innate neuroinflammatory response to functional recovery following pathology onset. This review will provide a general overview on the role of neuroinflammation in these neurodegenerative diseases and an update on NSAID treatment in recent experimental animal models, epidemiological analyses, and clinical trials.

Keywords: Non-steroidal anti-inflammatory drugs; Alzheimer's disease; Parkinson's disease; cyclooxygenase; neuroinflammation

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