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Pharmaceuticals 2010, 3(5), 1668-1693; doi:10.3390/ph3051668

Effect of Non-Steroidal Anti-Inflammatory Drugs on Bone Healing

 and *
Department of Biochemistry & Molecular Biology, University of Medicine and Dentistry of New Jersey—New Jersey Medical School, Newark, NJ 07013, USA
* Author to whom correspondence should be addressed.
Received: 9 April 2010 / Revised: 5 May 2010 / Accepted: 24 May 2010 / Published: 25 May 2010
(This article belongs to the collection Non-Steroidal Anti-Inflammatory Drugs)
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Nonspecific and COX-2 selective nonsteroidal anti-inflammatory drugs (NSAIDs) function by inhibiting the cyclooxygenase isoenzymes and effectively reduce pain and inflammation attributed to acute or chronic musculoskeletal pathologies. However, use of NSAIDs as an analgesic is thought to negatively contribute to bone healing. This review strived to provide a thorough unbiased analysis of the current research conducted on animals and humans regarding NSAIDs and their effect on bone healing. Specifically, this review discusses the role of animal models, dosing regiments, and outcome parameters when examining discrepancies about NSAIDS and their effects on bone regeneration. The role of COX-2 in bone regeneration needs to be better defined in order to further elucidate the impact of NSAIDs on bone healing.
Keywords: NSAIDs; bone healing; COX-2; COX-1; fracture NSAIDs; bone healing; COX-2; COX-1; fracture
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Cottrell, J.; O’Connor, J.P. Effect of Non-Steroidal Anti-Inflammatory Drugs on Bone Healing. Pharmaceuticals 2010, 3, 1668-1693.

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