Pharmaceuticals 2010, 3(4), 1187-1201; doi:10.3390/ph3041187
Review

A Review of Anti-Inflammatory Drug-Induced Gastrointestinal Injury: Focus on Prevention of Small Intestinal Injury

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Received: 16 March 2010; in revised form: 15 April 2010 / Accepted: 19 April 2010 / Published: 20 April 2010
(This article belongs to the collection Non-Steroidal Anti-Inflammatory Drugs)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Capsule endoscopy and balloon endoscopy, advanced modalities that allow full investigation of the entire small intestine, have revealed that nonsteroidal anti-inflammatory drugs (NSAIDs) can cause a variety of abnormalities in the small intestine. Recently, several reports show that traditional NSAIDs (tNSAIDs) and acetylsalicylic acid (ASA) can induce small intestinal injuries. These reports have shown that the preventive effect of proton pump inhibitors (PPIs) does not extend to the small intestine, suggesting that concomitant therapy may be required to prevent small intestinal side effects associated with tNSAID/ASA use. Recently, several randomized controlled trials used capsule endoscopy to evaluate the preventive effect of mucoprotective drugs against tNSAID/ASA-induced small intestinal injury. These studies show that misoprostol and rebamipide reduce the number and types of tNSAID-induced small intestinal mucosal injuries. However, those studies were limited to a small number of subjects and tested short-term tNSAID/ ASA treatment. Therefore, further extensive studies are clearly required to ascertain the beneficial effect of these drugs.
Keywords: NSAID; aspirin; small intestine; injury; misoprostol; rebamipide
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MDPI and ACS Style

Fujimori, S.; Gudis, K.; Sakamoto, C. A Review of Anti-Inflammatory Drug-Induced Gastrointestinal Injury: Focus on Prevention of Small Intestinal Injury. Pharmaceuticals 2010, 3, 1187-1201.

AMA Style

Fujimori S, Gudis K, Sakamoto C. A Review of Anti-Inflammatory Drug-Induced Gastrointestinal Injury: Focus on Prevention of Small Intestinal Injury. Pharmaceuticals. 2010; 3(4):1187-1201.

Chicago/Turabian Style

Fujimori, Shunji; Gudis, Katya; Sakamoto, Choitsu. 2010. "A Review of Anti-Inflammatory Drug-Induced Gastrointestinal Injury: Focus on Prevention of Small Intestinal Injury." Pharmaceuticals 3, no. 4: 1187-1201.

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