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Pharmaceuticals 2010, 3(12), 3614-3628; doi:10.3390/ph3123614
Review

Pharmacogenetics of SSRIs and Sexual Dysfunction

 and *
Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood St. Rm. 164 (M/C886), Chicago, IL 60612, USA
* Author to whom correspondence should be addressed.
Received: 1 November 2010 / Revised: 30 November 2010 / Accepted: 9 December 2010 / Published: 15 December 2010
(This article belongs to the Special Issue Antidepressants)
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Abstract

Sexual dysfunction (SD) is a common and disconcerting side effect of selective serotonin reuptake inhibitors (SSRIs) that often influences a patient’s desire to continue long-term antidepressant treatment. Studies specifically assessing changes in sexual well-being over time illustrate that the incidence of sexual side effects from SSRIs ranges from 20% to 70%, depending on the characteristics of the study sample assessed. Developing strategies to predict who may be at the highest risk for adverse changes in their sexual well-being is an important step in improving the quality of life and treatment of patients who require antidepressant therapy. Pharmacogenetic studies of SSRI-associated SD have identified associations between serotonin and glutamate system genes with aspects of SD. The results of studies investigating genetic variations in drug metabolism enzymes and their relationships to antidepressant-associated adverse effects have been mixed. Continued efforts to characterize the relationships between genetic markers and antidepressant outcomes, and to translate this knowledge to patient care, have the potential to significantly improve the empiric selection of antidepressant agents and to minimize the risk for intolerable side effects.
Keywords: SSRI; sexual dysfunction; polymorphism; serotonin; glutamate; drug metabolism; depression SSRI; sexual dysfunction; polymorphism; serotonin; glutamate; drug metabolism; depression
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Osis, L.; Bishop, J.R. Pharmacogenetics of SSRIs and Sexual Dysfunction. Pharmaceuticals 2010, 3, 3614-3628.

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