Next Article in Journal
Brain CB2 Receptors: Implications for Neuropsychiatric Disorders
Next Article in Special Issue
Non-Steroidal Anti-Inflammatory Drugs, Variation in Inflammatory Genes, and Aggressive Prostate Cancer
Previous Article in Journal
Use of Generics—A Critical Cost Containment Measure for All Healthcare Professionals in Europe?
Previous Article in Special Issue
Nonsteroidal Anti-Inflammatory Drugs and the Kidney
Pharmaceuticals 2010, 3(8), 2495-2516; doi:10.3390/ph3082495
Review

Non-Steroidal Anti-Inflammatory Drugs in the Carcinogenesis of the Gastrointestinal Tract

,
 and
*
Received: 20 July 2010 / Revised: 27 July 2010 / Accepted: 6 August 2010 / Published: 9 August 2010
(This article belongs to the collection Non-Steroidal Anti-Inflammatory Drugs)
View Full-Text   |   Download PDF [191 KB, uploaded 9 August 2010]

Abstract

It is estimated that underlying infections and inflammatory responses are linked to 15–20% of all deaths from cancer worldwide. Inflammation is a physiologic process in response to tissue damage resulting from microbial pathogen infection, chemical irritation, and/or wounding. Tissues injured throughout the recruitment of inflammatory cells such as macrophages and neutrophils, generate a great amount of growth factors, cytokines, and reactive oxygen and nitrogen species that may cause DNA damage that in turn predisposes to the transformation from chronic inflammation to neoplasia. Cyclooxygenase (COX), playing a key role in cell homeostasis, angiogenesis and tumourigenesis, may represent the link between inflammation and cancer. Currently COX is becoming a pharmacological target for cancer prevention and treatment.It is estimated that underlying infections and inflammatory responses are linked to 15–20% of all deaths from cancer worldwide. Inflammation is a physiologic process in response to tissue damage resulting from microbial pathogen infection, chemical irritation, and/or wounding. Tissues injured throughout the recruitment of inflammatory cells such as macrophages and neutrophils, generate a great amount of growth factors, cytokines, and reactive oxygen and nitrogen species that may cause DNA damage that in turn predisposes to the transformation from chronic inflammation to neoplasia. Cyclooxygenase (COX), playing a key role in cell homeostasis, angiogenesis and tumourigenesis, may represent the link between inflammation and cancer. Currently COX is becoming a pharmacological target for cancer prevention and treatment.
Keywords: cyclooxygenase-2; non-steroidal anti-inflammatory drugs; esophageal cancer; gastric cancer; colorectal cancer cyclooxygenase-2; non-steroidal anti-inflammatory drugs; esophageal cancer; gastric cancer; colorectal cancer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Compare, D.; Nardone, O.; Nardone, G. Non-Steroidal Anti-Inflammatory Drugs in the Carcinogenesis of the Gastrointestinal Tract. Pharmaceuticals 2010, 3, 2495-2516.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Pharmaceuticals EISSN 1424-8247 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert