Effect of Different Metal Ions on the Biological Properties of Cefadroxil
Abstract
:1. Introduction
2. Results and Discussion
2.1. Uptake and transport studies
2.2. Antibacterial activity tests
Bacteria | Inhibition zone (mm) | |||
---|---|---|---|---|
Cefadroxil | Cef-Zn | Cef-Cu | Cef-Al | |
E. coli | 11.5 ± 0.4 | 12.2 ± 0.3 | 9.2 ± 0.4 | 9.7 ± 0.3 |
S. carnosus | 32.3 ± 0.8 | 33.2 ± 0.8 | 33.3 + 0.9 | 32.5 ± 1.4 |
P. vulgaris | 0.0 | 0.0 | 0.0 | 0.0 |
B. subtilis | 33.2 ± 0.6 | 33.8 ± 0.6 | 34.0 ± 0.6 | 34,0 ± 0.6 |
P. putida | 0.0 | 0.0 | 0.0 | 0.0 |
M. luteus | 31.0 ± 0.7 | 32.8 ± 0.3 | 32.7 ± 0.4 | 32.7 ± 0.4 |
3. Experimental
3.1. Materials
3.2. Caco-2 cell culture and uptake assessments
3.3. HPLC analysis
3.4. Antimicrobial activity test
3.5. Calculations and Statistics
4. Conclusion
Acknowledgements
References and Notes
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Auda, S.H.; Knütter, I.; Bretschneider, B.; Brandsch, M.; Mrestani, Y.; Große, C.; Neubert, R.H.H. Effect of Different Metal Ions on the Biological Properties of Cefadroxil. Pharmaceuticals 2009, 2, 184-193. https://doi.org/10.3390/ph2030184
Auda SH, Knütter I, Bretschneider B, Brandsch M, Mrestani Y, Große C, Neubert RHH. Effect of Different Metal Ions on the Biological Properties of Cefadroxil. Pharmaceuticals. 2009; 2(3):184-193. https://doi.org/10.3390/ph2030184
Chicago/Turabian StyleAuda, Sayed H., Ilka Knütter, Beate Bretschneider, Matthias Brandsch, Yahya Mrestani, Cornelia Große, and Reinhard H. H. Neubert. 2009. "Effect of Different Metal Ions on the Biological Properties of Cefadroxil" Pharmaceuticals 2, no. 3: 184-193. https://doi.org/10.3390/ph2030184