Abstract: The prevention of aging is one of the most fascinating areas in biomedicine. The first step in the development of effective drugs for aging prevention is a knowledge of the biochemical pathways responsible for the cellular aging process. In this context it seems clear that free radicals play a key role in the aging process. However, in recent years it has been demonstrated that the families of enzymes called sirtuins, specifically situin 1 (SIRT1), have an anti-aging action. Thus, the natural compound resveratrol is a natural compound that shows a very strong activation of SIRT1 and also shows antioxidant effects. By activating sirtuin 1, resveratrol modulates the activity of numerous proteins, including peroxisome proliferator-activated receptor coactivator-1α (PGC-1 alpha), the FOXO family, Akt (protein kinase B) and NFκβ. In the present review, we suggest that resveratrol may constitute a potential drug for prevention of ageing and for the treatment of several diseases due to its antioxidant properties and sirtuin activation.
Keywords: resveratrol; Alzheimer’s disease; Parkinson’s disease; SIRT1
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Camins, A.; Junyent, F.; Verdaguer, E.; Beas-Zarate, C.; Rojas-Mayorquín, A.E.; Ortuño-Sahagún, D.; Pallàs, M. Resveratrol: An Antiaging Drug with Potential Therapeutic Applications in Treating Diseases. Pharmaceuticals 2009, 2, 194-205.
Camins A, Junyent F, Verdaguer E, Beas-Zarate C, Rojas-Mayorquín AE, Ortuño-Sahagún D, Pallàs M. Resveratrol: An Antiaging Drug with Potential Therapeutic Applications in Treating Diseases. Pharmaceuticals. 2009; 2(3):194-205.
Camins, Antoni; Junyent, Felix; Verdaguer, Ester; Beas-Zarate, Carlos; Rojas-Mayorquín, Argelia E.; Ortuño-Sahagún, Daniel; Pallàs, Mercè. 2009. "Resveratrol: An Antiaging Drug with Potential Therapeutic Applications in Treating Diseases." Pharmaceuticals 2, no. 3: 194-205.