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Sensors 2009, 9(6), 4407-4445; doi:10.3390/s90604407

Antibody-Based Sensors: Principles, Problems and Potential for Detection of Pathogens and Associated Toxins

1
Centre for Bioanalytical Sciences (CBAS), Dublin City University, Dublin 9, Ireland
2
National Centre for Sensor Research (NCSR), Dublin City University, Dublin 9, Ireland
3
Biomedical Diagnostics Institute (BDI), Dublin City University, Dublin 9, Ireland
*
Author to whom correspondence should be addressed.
Received: 7 April 2009 / Revised: 26 May 2009 / Accepted: 26 May 2009 / Published: 5 June 2009
(This article belongs to the Special Issue Pathogen Sensors)
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Abstract

Antibody-based sensors permit the rapid and sensitive analysis of a range of pathogens and associated toxins. A critical assessment of the implementation of such formats is provided, with reference to their principles, problems and potential for ‘on-site’ analysis. Particular emphasis is placed on the detection of foodborne bacterial pathogens, such as Escherichia coli and Listeria monocytogenes, and additional examples relating to the monitoring of fungal pathogens, viruses, mycotoxins, marine toxins and parasites are also provided.
Keywords: pathogen; antibody; biosensor; electrochemical; surface-plasmon resonance; assay development pathogen; antibody; biosensor; electrochemical; surface-plasmon resonance; assay development
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Byrne, B.; Stack, E.; Gilmartin, N.; O’Kennedy, R. Antibody-Based Sensors: Principles, Problems and Potential for Detection of Pathogens and Associated Toxins. Sensors 2009, 9, 4407-4445.

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