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Sensors 2009, 9(6), 4483-4502; doi:10.3390/s90604483

An Overview of Recent Strategies in Pathogen Sensing

1,2 and 1,2,*
1 Bio-MEMS and Biomaterials Laboratory, Department of Mechanical and Aerospace Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA 2 Department of Physiology and Biophysics, University at Buffalo, The State University of New York, Buffalo, NY 14241, USA
* Author to whom correspondence should be addressed.
Received: 27 April 2009 / Revised: 31 May 2009 / Accepted: 8 June 2009 / Published: 8 June 2009
(This article belongs to the Special Issue Pathogen Sensors)
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Pathogenic bacteria are one of the major concerns in food industries and water treatment facilities because of their rapid growth and deleterious effects on human health. The development of fast and accurate detection and identification systems for bacterial strains has long been an important issue to researchers. Although confirmative for the identification of bacteria, conventional methods require time-consuming process involving either the test of characteristic metabolites or cellular reproductive cycles. In this paper, we review recent sensing strategies based on micro- and nano-fabrication technology. These technologies allow for a great improvement of detection limit, therefore, reduce the time required for sample preparation. The paper will be focused on newly developed nano- and micro-scaled biosensors, novel sensing modalities utilizing microfluidic lab-on-a-chip, and array technology for the detection of pathogenic bacteria.
Keywords: pathogen; microfabrication; nanofabrication; lab-on-a-chip; microfluidics pathogen; microfabrication; nanofabrication; lab-on-a-chip; microfluidics
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Heo, J.; Hua, S.Z. An Overview of Recent Strategies in Pathogen Sensing. Sensors 2009, 9, 4483-4502.

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