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Sensors 2009, 9(6), 4309-4322; doi:10.3390/s90604309

Development of Membrane Selective Electrode for Determination of the Antipsychotic Sulpiride in Pharmaceuticals and Urine

Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, 30071-Murcia, Spain
Author to whom correspondence should be addressed.
Received: 20 April 2009 / Revised: 27 May 2009 / Accepted: 1 June 2009 / Published: 3 June 2009
(This article belongs to the Section Chemical Sensors)
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The construction and electrochemical response characteristics of a poly(vinyl chloride) (PVC) membrane selective electrode for the determination of sulpiride (SPD) are described. The sensing membrane comprised an ion-exchanger formed between the protonated drug and tetraphenylborate (TPB-) in a plasticized PVC matrix. The influence of membrane composition on the electrode response was studied. The electrode showed a fast, stable and Nernstian response over a sulpiride concentration range (1 × 10-4– 1 × 10-2 M) with a mean slope of 58.4 ± 0.9 mV dec-1 of concentration, a mean detection limit of 4.2 × 10-5 ± 1.2 × 10-5 M, a wide working pH range (2 – 8) and a fast response time (< 15 s). The electrode showed good selectivity towards sulpiride with respect to some inorganic and organic compounds. When the electrode was applied to the determination of sulpiride in pharmaceuticals and human urine, a high percentage of recovery was attained with no need for sample pretreatment procedures because of the lack of interfering matrix effects. View Full-Text
Keywords: ion-selective electrode; sulpiride determination; pharmaceuticals; urine ion-selective electrode; sulpiride determination; pharmaceuticals; urine

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

García, M.S.; Ortuño, J.A.; Albero, M.I.; Abuherba, M.S. Development of Membrane Selective Electrode for Determination of the Antipsychotic Sulpiride in Pharmaceuticals and Urine. Sensors 2009, 9, 4309-4322.

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