Next Article in Journal
Solid State Gas Sensor Research in Germany – a Status Report
Previous Article in Journal
RoPEUS: A New Robust Algorithm for Static Positioning in Ultrasonic Systems
Article Menu

Export Article

Open AccessArticle
Sensors 2009, 9(6), 4309-4322; doi:10.3390/s90604309

Development of Membrane Selective Electrode for Determination of the Antipsychotic Sulpiride in Pharmaceuticals and Urine

Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, 30071-Murcia, Spain
*
Author to whom correspondence should be addressed.
Received: 20 April 2009 / Revised: 27 May 2009 / Accepted: 1 June 2009 / Published: 3 June 2009
(This article belongs to the Section Chemical Sensors)
View Full-Text   |   Download PDF [268 KB, uploaded 21 June 2014]   |  

Abstract

The construction and electrochemical response characteristics of a poly(vinyl chloride) (PVC) membrane selective electrode for the determination of sulpiride (SPD) are described. The sensing membrane comprised an ion-exchanger formed between the protonated drug and tetraphenylborate (TPB-) in a plasticized PVC matrix. The influence of membrane composition on the electrode response was studied. The electrode showed a fast, stable and Nernstian response over a sulpiride concentration range (1 × 10-4– 1 × 10-2 M) with a mean slope of 58.4 ± 0.9 mV dec-1 of concentration, a mean detection limit of 4.2 × 10-5 ± 1.2 × 10-5 M, a wide working pH range (2 – 8) and a fast response time (< 15 s). The electrode showed good selectivity towards sulpiride with respect to some inorganic and organic compounds. When the electrode was applied to the determination of sulpiride in pharmaceuticals and human urine, a high percentage of recovery was attained with no need for sample pretreatment procedures because of the lack of interfering matrix effects. View Full-Text
Keywords: ion-selective electrode; sulpiride determination; pharmaceuticals; urine ion-selective electrode; sulpiride determination; pharmaceuticals; urine
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

García, M.S.; Ortuño, J.A.; Albero, M.I.; Abuherba, M.S. Development of Membrane Selective Electrode for Determination of the Antipsychotic Sulpiride in Pharmaceuticals and Urine. Sensors 2009, 9, 4309-4322.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top