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Sensors 2009, 9(6), 4022-4033; doi:10.3390/s90604022

Magneto-Optical Relaxation Measurements of Functionalized Nanoparticles as a Novel Biosensor

* ,
University of Greifswald, Institute of Pharmacy, F.-L.-Jahn-Strasse 17, 17487 Greifswald, Germany
* Author to whom correspondence should be addressed.
Received: 27 March 2009 / Revised: 21 May 2009 / Accepted: 25 May 2009 / Published: 26 May 2009
(This article belongs to the Special Issue State-of-the-Art Sensors Technology in Germany)
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Measurements of magneto-optical relaxation signals of magnetic nanoparticles functionalized with biomolecules are a novel biosensing tool. Upon transmission of a laser beam through a nanoparticle suspension in a pulsed magnetic field, the properties of the laser beam change. This can be detected by optical methods. Biomolecular binding events leading to aggregation of nanoparticles are ascertainable by calculating the relaxation time and from this, the hydrodynamic diameters of the involved particles from the optical signal. Interaction between insulin-like growth factor 1 (IGF-1) and its antibody was utilized for demonstration of the measurement setup applicability as an immunoassay. Furthermore, a formerly developed kinetic model was utilized in order to determine kinetic parameters of the interaction. Beside utilization of the method as an immunoassay it can be applied for the characterization of diverse magnetic nanoparticles regarding their size and size distribution.
Keywords: magnetic nanoparticles; magneto-optical relaxation; immunoassay; IGF-1 assay magnetic nanoparticles; magneto-optical relaxation; immunoassay; IGF-1 assay
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Aurich, K.; Glöckl, G.; Nagel, S.; Weitschies, W. Magneto-Optical Relaxation Measurements of Functionalized Nanoparticles as a Novel Biosensor. Sensors 2009, 9, 4022-4033.

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