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Sensors 2009, 9(5), 3437-3446; doi:10.3390/s90503437
Article

A Butyl Methacrylate Monolithic Column Prepared In-Situ on a Microfluidic Chip and its Applications

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Received: 6 February 2009; in revised form: 3 March 2009 / Accepted: 21 April 2009 / Published: 8 May 2009
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Abstract: A butyl methacrylate (BMA) monolithic column was polymerized in-situ with UV irradiation in an ultraviolet transparent PDMS micro-channel on a homemade micro-fluidic chip. Under the optimized conditions and using a typical polymerization mixture consisting of 75% porogenic solvents and 25% monomers, the BMA monolithic column was obtained as expected. The BET surface area ratio of the BMA monolithic column was 366 m2·g-1. The corresponding SEM images showed that the monolithic column material polymerized in a glass channel was composed of uniform pores and spherical particles with diameters ranging from 3 to 5 μm. The promethazine–luminal–potassium ferricyanide chemiluminescence system was selected for testing the capability of the column. A flow injection analytical technique–chemiluminescence (FIA–CL) system on the microfluidic chip with a BMA monolithic column pretreatment unit was established to determine promethazine. Trace promethazine was enriched by the BMA monolithic column, with more than a 10-fold average enrichment ratio. The proposed method has a linear response concentration range of 1.0×10-8 - 1.0×10-6g·mL-1 and the detection limit was 1.6×10-9g·mL-1.
Keywords: BMA monolithic column; separation and preconcentration; microfluidic chip BMA monolithic column; separation and preconcentration; microfluidic chip
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Xu, Y.; Zhang, W.; Zeng, P.; Cao, Q. A Butyl Methacrylate Monolithic Column Prepared In-Situ on a Microfluidic Chip and its Applications. Sensors 2009, 9, 3437-3446.

AMA Style

Xu Y, Zhang W, Zeng P, Cao Q. A Butyl Methacrylate Monolithic Column Prepared In-Situ on a Microfluidic Chip and its Applications. Sensors. 2009; 9(5):3437-3446.

Chicago/Turabian Style

Xu, Yi; Zhang, Wenpin; Zeng, Ping; Cao, Qiang. 2009. "A Butyl Methacrylate Monolithic Column Prepared In-Situ on a Microfluidic Chip and its Applications." Sensors 9, no. 5: 3437-3446.



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