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Sensors 2009, 9(4), 2524-2537; doi:10.3390/s90402524
Article

An Adaptable, Portable Microarray Reader for Biodetection

1
, 2, †
, 2, 1, †
, 1, 3
, 1, †
, 1, 4,*  and 1, 2, 5,*
1 NSF – Center for Biophotonics Science and Technology, University of California Davis / 2700 Stockton Blvd. Sacramento CA 95817, USA 2 Lawrence Livermore National Laboratory / 7000 East Ave., Livermore, CA 94550, USA 3 University of California, Davis Medical Center, Department of Neurological Surgery / 860 Y St., Suite 3740 | Sacramento, CA 95817, USA 4 University of California, Davis Medical Center, Department of Pathology and Laboratory Medicine / 4400 V Street | Sacramento, CA 95817, USA 5 University of California, Davis Medical Center, Department of Radiation Oncology / 4501 X Street, Suite G-140 | Sacramento, CA 95817, USA Current affil.: Microchip Biotechnologies, Inc., 6693 Sierra Lane, Suite F., Dublin, CA 94568, USA (F.P.); Abbott Laboratories, 5440 Patrick Henry Dr., Santa Clara, CA 95054, USA (R.R.); Univ. of the Pacific, 3601 Pacific Avenue, Stockton, CA 95211, USA
* Authors to whom correspondence should be addressed.
Received: 25 February 2009 / Revised: 7 April 2009 / Accepted: 14 April 2009 / Published: 14 April 2009
(This article belongs to the Section Biosensors)
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Abstract

We have developed an inexpensive portable microarray reader that can be applied to standard microscope slide-based arrays and other array formats printed on chemically modified surfaces. Measuring only 19 cm in length, the imaging device is portable and may be applicable to both triage and clinical settings. For multiplexing and adaptability purposes, it can be modified to work with multiple excitation/emission wavelengths. Our device is shown to be comparable to a commercial laser scanner when detecting both streptavidin-biotin and antibody interactions. This paper presents the development and characterization of a handheld microarray imager and directly compares it with a commercial scanner.
Keywords: Microarrays; immunoassays; protein arrays; point-of-care diagnostics; portable microarray reader Microarrays; immunoassays; protein arrays; point-of-care diagnostics; portable microarray reader
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Thompson, D.L.; Pearson, F.; Thomas, C.; Rao, R.; Matthews, D.; Albala, J.S.; Wachsmann-Hogiu, S.; Coleman, M.A. An Adaptable, Portable Microarray Reader for Biodetection. Sensors 2009, 9, 2524-2537.

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