Next Article in Journal
Biomimetic Yeast Cell Typing—Application of QCMs
Next Article in Special Issue
Editorial: Nanotechnological Advances in Biosensors
Previous Article in Journal
Guest Editor’s Concluding Remarks―Advances in Usage of ANN, Discussion of an Unsolved Problem, and Some Differences between Papers Written by Engineers and by Physicians
Previous Article in Special Issue
Detecting Proteins in Highly Autofluorescent Cells Using Quantum Dot Antibody Conjugates
Sensors 2009, 9(10), 8130-8145; doi:10.3390/s91008130
Review

Magnetic Nanoparticle Sensors

1
 and 2,*
1 T2 Biosystems, 286 Cardinal Medieros Ave, Cambridge, MA 02141, USA 2 Center for Translational Nuclear Medicine, Department of Nuclear Medicine and Molecular Imaging and Center for Molecular Imaging Research, Massachusetts General Hospital/Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
* Author to whom correspondence should be addressed.
Received: 3 August 2009 / Revised: 29 September 2009 / Accepted: 30 September 2009 / Published: 16 October 2009
(This article belongs to the Special Issue Nanotechnological Advances in Biosensors)
View Full-Text   |   Download PDF [437 KB, uploaded 21 June 2014]   |   Browse Figures

Abstract

Many types of biosensors employ magnetic nanoparticles (diameter = 5–300 nm) or magnetic particles (diameter = 300–5,000 nm) which have been surface functionalized to recognize specific molecular targets. Here we cover three types of biosensors that employ different biosensing principles, magnetic materials, and instrumentation. The first type consists of magnetic relaxation switch assay-sensors, which are based on the effects magnetic particles exert on water proton relaxation rates. The second type consists of magnetic particle relaxation sensors, which determine the relaxation of the magnetic moment within the magnetic particle. The third type is magnetoresistive sensors, which detect the presence of magnetic particles on the surface of electronic devices that are sensitive to changes in magnetic fields on their surface. Recent improvements in the design of magnetic nanoparticles (and magnetic particles), together with improvements in instrumentation, suggest that magnetic material-based biosensors may become widely used in the future.
Keywords: magnetic particles; magnetic nanoparticles; target molecules; biosensors; magnetization magnetic particles; magnetic nanoparticles; target molecules; biosensors; magnetization
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Export to BibTeX |
EndNote


MDPI and ACS Style

Koh, I.; Josephson, L. Magnetic Nanoparticle Sensors. Sensors 2009, 9, 8130-8145.

View more citation formats

Related Articles

Article Metrics

Comments

Citing Articles

[Return to top]
Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert