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Sensors 2009, 9(10), 8146-8157; doi:10.3390/s91008146

Biomimetic Yeast Cell Typing—Application of QCMs

University of Vienna, Department of Analytical Chemistry and Food Chemistry, Faculty of Chemistry, Waehringer Strasse 38, A-1090 Vienna, Austria
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Received: 17 August 2009 / Revised: 22 September 2009 / Accepted: 25 September 2009 / Published: 16 October 2009
(This article belongs to the Section Chemical Sensors)
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Abstract

Artificial antibodies represent a key factor in the generation of sensing systems for the selective detection of bioanalytes of variable sizes. With biomimetic surfaces, the important model organism Saccharomyces cerevisiae and several of its growth stages may be detected. Quartz crystal microbalances (QCM) with 10 MHz fundamental frequency and coated with polymers imprinted with synchronized yeast cells are presented, which are able to detect duplex cells with high selectivity. Furthermore, a multichannel quartz crystal microbalance (MQCM) was designed and optimized for the measurement in liquids. This one-chip system based on four-electrode geometry allows the simultaneous detection of four analytes and, thus, provides a monitoring system for biotechnology and process control. For further standardization of the method, synthetic stamps containing plastic yeast cells in different growth stages were produced and utilized for imprinting. Mass-sensitive measurements with such MIPs resulted in the same sensor characteristics as obtained for those imprinted with native yeast cells. View Full-Text
Keywords: molecular imprinting; yeast; QCM; bioanalyte sensing; process control molecular imprinting; yeast; QCM; bioanalyte sensing; process control
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MDPI and ACS Style

Seidler, K.; Polreichová, M.; Lieberzeit, P.A.; Dickert, F.L. Biomimetic Yeast Cell Typing—Application of QCMs. Sensors 2009, 9, 8146-8157.

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