Bacterial Biosensors for Measuring Availability of Environmental Pollutants
AbstractTraditionally, pollution risk assessment is based on the measurement of a pollutant’s total concentration in a sample. The toxicity of a given pollutant in the environment, however, is tightly linked to its bioavailability, which may differ significantly from the total amount. Physico-chemical and biological parameters strongly influence pollutant fate in terms of leaching, sequestration and biodegradation. Bacterial sensorreporters, which consist of living micro-organisms genetically engineered to produce specific output in response to target chemicals, offer an interesting alternative to monitoring approaches. Bacterial sensor-reporters detect bioavailable and/or bioaccessible compound fractions in samples. Currently, a variety of environmental pollutants can be targeted by specific biosensor-reporters. Although most of such strains are still confined to the lab, several recent reports have demonstrated utility of bacterial sensing-reporting in the field, with method detection limits in the nanomolar range. This review illustrates the general design principles for bacterial sensor-reporters, presents an overview of the existing biosensor-reporter strains with emphasis on organic compound detection. A specific focus throughout is on the concepts of bioavailability and bioaccessibility, and how bacteria-based sensing-reporting systems can help to improve our basic understanding of the different processes at work.
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Tecon, R.; Van der Meer, J.R. Bacterial Biosensors for Measuring Availability of Environmental Pollutants. Sensors 2008, 8, 4062-4080.
Tecon R, Van der Meer JR. Bacterial Biosensors for Measuring Availability of Environmental Pollutants. Sensors. 2008; 8(7):4062-4080.Chicago/Turabian Style
Tecon, Robin; Van der Meer, Jan R. 2008. "Bacterial Biosensors for Measuring Availability of Environmental Pollutants." Sensors 8, no. 7: 4062-4080.