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Cross-Reactive Sensor Array for Metal Ion Sensing Based on Fluorescent SAMs
Department of Supramolecular Chemistry and Technology, MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands
* Author to whom correspondence should be addressed.
Received: 20 August 2007; Accepted: 4 September 2007 / Published: 5 September 2007
Abstract: Fluorescent self assembled monolayers (SAMs) on glass were previouslydeveloped in our group as new sensing materials for metal ions. These fluorescent SAMs arecomprised by fluorophores and small molecules sequentially deposited on a monolayer onglass. The preorganization provided by the surface avoids the need for complex receptordesign, allowing for a combinatorial approach to sensing systems based on small molecules.Now we show the fabrication of an effective microarray for the screening of metal ions andthe properties of the sensing SAMs. A collection of fluorescent sensing SAMs wasgenerated by combinatorial methods and immobilized on the glass surfaces of a custom-made 140 well microtiter-plate. The resulting libraries are easily measured and show variedresponses to a series cations such as Cu2+ , Co2+ , Pb2+ , Ca2+ and Zn2+ . These surfaces are notdesigned to complex selectively a unique analyte but rather they are intended to producefingerprint type responses to a range of analytes by less specific interactions. The unselectiveresponses of the library to the presence of different cations generate a characteristic patternfor each analyte, a “finger print” response.
Keywords: High throughput; fluorescence; SAMs; microtiter plate; differential sensing; sensor array; metal ions
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MDPI and ACS Style
Basabe-Desmonts, L.; Van der Baan, F.; Zimmerman, R.S.; Reinhoudt, D.N.; Crego-Calama, M. Cross-Reactive Sensor Array for Metal Ion Sensing Based on Fluorescent SAMs. Sensors 2007, 7, 1731-1746.
Basabe-Desmonts L, Van der Baan F, Zimmerman RS, Reinhoudt DN, Crego-Calama M. Cross-Reactive Sensor Array for Metal Ion Sensing Based on Fluorescent SAMs. Sensors. 2007; 7(9):1731-1746.
Basabe-Desmonts, Lourdes; Van der Baan, Frederieke; Zimmerman, Rebecca S.; Reinhoudt, David N.; Crego-Calama, Mercedes. 2007. "Cross-Reactive Sensor Array for Metal Ion Sensing Based on Fluorescent SAMs." Sensors 7, no. 9: 1731-1746.