Sensors 2007, 7(10), 2096-2114; doi:10.3390/s7102096
Article

Synthesis, Characterization and Metal Ion Detection of Novel Fluoroionophores Based on Heterocyclic Substituted Alanines

1 Centro de Química, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal 2 REQUIMTE, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829-516 Monte de Caparica, Portugal
* Author to whom correspondence should be addressed.
Received: 19 September 2007; Accepted: 27 September 2007 / Published: 3 October 2007
(This article belongs to the Special Issue Supramolecular Sensors)
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Abstract: The synthesis of new fluorescent probes containing the thiophene andbenzoxazole moieties combined with an alanine residue is described. The resulting highlyfluorescent heterocyclic alanine derivatives respond via a quenching effect, withparamagnetic Cu(II) and Ni(II) metal ions and with diamagnetic Hg(II), as shown by theabsorption and steady-state fluorescence spectroscopy studies. The formation ofmononuclear or dinuclear metal complexes was postulated based on the presence of thefree carboxylic acid as binding site and also with the interaction with the donor atoms inthe chromophore. Interaction with other important biological metal ions such as Zn(II),Ca(II) and Na(I) was also explored.
Keywords: Benzoxazole; Thiophene; Amino acids; Fluorescence; Fluorescent probes.

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MDPI and ACS Style

Costa, S.P.G.; Oliveira, E.; Lodeiro, C.; Raposo, M.M.M. Synthesis, Characterization and Metal Ion Detection of Novel Fluoroionophores Based on Heterocyclic Substituted Alanines. Sensors 2007, 7, 2096-2114.

AMA Style

Costa SPG, Oliveira E, Lodeiro C, Raposo MMM. Synthesis, Characterization and Metal Ion Detection of Novel Fluoroionophores Based on Heterocyclic Substituted Alanines. Sensors. 2007; 7(10):2096-2114.

Chicago/Turabian Style

Costa, Susana P.G.; Oliveira, Elisabete; Lodeiro, Carlos; Raposo, M. M.M. 2007. "Synthesis, Characterization and Metal Ion Detection of Novel Fluoroionophores Based on Heterocyclic Substituted Alanines." Sensors 7, no. 10: 2096-2114.

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