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Indium Tin Oxide-Polyaniline Biosensor: Fabrication and Characterization
Biosystems and Agricultural Engineering, Michigan State University, East Lansing, MI 48824, USA
Large Animal Clinical Sciences, Michigan State University, East Lansing, MI 48824, USA
* Author to whom correspondence should be addressed.
Received: 6 December 2006; Accepted: 7 June 2007 / Published: 9 July 2007
Abstract: In this study, a novel indium tin oxide (ITO)-polyaniline (Pani) biosensor wasdesigned, fabricated, and characterized. Initial testing was conducted for the detection ofbovine viral diarrhea virus (BVDV). The biosensor design was based upon the specific natureof antibodies to capture the target virus, and the conductive properties of self-doped Pani totranslate the antibody-antigen binding into a quantifying signal. The first part of the study wasto assess the feasibility of the self-doped Pani to be incorporated into the biosensor design byevaluating its several parameters, such as conductivity, physical structure, thermogravimetricproperties, and antibody-binding properties. The second part of the paper highlights thefabrication of the ITO-Pani biosensor to detect the presence of bovine viral diarrhea virus(BVDV) in pure culture. Although only BVDV culture was tested in this study, the biosensoris versatile for the detection of other pathogen of interest by changing the specificity of theantibodies.
Keywords: self-doped polyaniline; biosensor; immunosensor; and pathogen detection
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Cite This Article
MDPI and ACS Style
Tahir, Z.M.; Alocilja, E.C.; Grooms, D.L. Indium Tin Oxide-Polyaniline Biosensor: Fabrication and Characterization. Sensors 2007, 7, 1123-1140.
Tahir ZM, Alocilja EC, Grooms DL. Indium Tin Oxide-Polyaniline Biosensor: Fabrication and Characterization. Sensors. 2007; 7(7):1123-1140.
Tahir, Zarini M.; Alocilja, Evangelyn C.; Grooms, Daniel L. 2007. "Indium Tin Oxide-Polyaniline Biosensor: Fabrication and Characterization." Sensors 7, no. 7: 1123-1140.