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Sensors 2007, 7(10), 2316-2329; doi:10.3390/s7102316

Non-invasive Optical Biosensor for Probing Cell Signaling

Biochemical Technologies, Science and Technology Division, Corning Incorporated, Sullivan Park, Corning, NY 14831, USA
Received: 24 September 2007 / Accepted: 15 October 2007 / Published: 16 October 2007
(This article belongs to the Special Issue Optical Biosensors)
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Cell signaling mediated through a cellular target is encoded by spatial andtemporal dynamics of downstream signaling networks. The coupling of temporal dynamicswith spatial gradients of signaling activities guides cellular responses upon stimulation.Monitoring the integration of cell signaling in real time, if realized, would provide a newdimension for understanding cell biology and physiology. Optical biosensors includingresonant waveguide grating (RWG) biosensor manifest a physiologically relevant andintegrated cellular response related to dynamic redistribution of cellular matters, thusproviding a non-invasive means for cell signaling study. This paper reviews recentprogresses in biosensor instrumentation, and theoretical considerations and potentialapplications of optical biosensors for whole cell sensing.
Keywords: Optical biosensor; resonant waveguide grating biosensor; cell signaling; G protein-coupled receptor; dynamic mass redistribution. Optical biosensor; resonant waveguide grating biosensor; cell signaling; G protein-coupled receptor; dynamic mass redistribution.
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fang, Y. Non-invasive Optical Biosensor for Probing Cell Signaling. Sensors 2007, 7, 2316-2329.

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