Next Article in Journal / Special Issue
Synthesis of a Molecularly Imprinted Polymer for Dioxin
Previous Article in Journal / Special Issue
A New Composition for Co(II)-porphyrin-based Membranes Used in Thiocyanate-selective Electrodes
Sensors 2006, 6(8), 901-914; doi:10.3390/s6080901
Review

Uses of Dendrimers for DNA Microarrays

* ,
,
,
 and *
Received: 27 April 2006; Accepted: 27 July 2006 / Published: 24 August 2006
(This article belongs to the Special Issue Supramolecular Sensors)
View Full-Text   |   Download PDF [2631 KB, uploaded 21 June 2014]   |   Browse Figures
Abstract: Biosensors such as DNA microarrays and microchips are gaining an increasingimportance in medicinal, forensic, and environmental analyses. Such devices are based onthe detection of supramolecular interactions called hybridizations that occur betweencomplementary oligonucleotides, one linked to a solid surface (the probe), and the other oneto be analyzed (the target). This paper focuses on the improvements that hyperbranched andperfectly defined nanomolecules called dendrimers can provide to this methodology. Twomain uses of dendrimers for such purpose have been described up to now; either thedendrimer is used as linker between the solid surface and the probe oligonucleotide, or thedendrimer is used as a multilabeled entity linked to the target oligonucleotide. In the firstcase the dendrimer generally induces a higher loading of probes and an easier hybridization,due to moving away the solid phase. In the second case the high number of localized labels(generally fluorescent) induces an increased sensitivity, allowing the detection of smallquantities of biological entities.
Keywords: dendrimers; microarrays; fluorescence; DNA; dendrons dendrimers; microarrays; fluorescence; DNA; dendrons
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Caminade, A.-M.; Padié, C.; Laurent, R.; Maraval, A.; Majoral, J.-P. Uses of Dendrimers for DNA Microarrays. Sensors 2006, 6, 901-914.

AMA Style

Caminade A-M, Padié C, Laurent R, Maraval A, Majoral J-P. Uses of Dendrimers for DNA Microarrays. Sensors. 2006; 6(8):901-914.

Chicago/Turabian Style

Caminade, Anne-Marie; Padié, Clément; Laurent, Régis; Maraval, Alexandrine; Majoral, Jean-Pierre. 2006. "Uses of Dendrimers for DNA Microarrays." Sensors 6, no. 8: 901-914.


Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert