CiteULike
Facebook
Mendeley
Twitter
This article is- freely available
- re-usable
Sensors 2005, 5(6), 317-342; doi:10.3390/s5060317
Review
Long-Term Monitoring of Brain Dopamine Metabolism In Vivo with Carbon Paste Electrodes
UCD School of Chemistry & Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland
Received: 4 April 2005 / Accepted: 28 April 2005 / Published: 14 November 2005
(This article belongs to the Special Issue Carbon Paste Electrodes)
Download PDF Full-Text [207 KB, uploaded 20 June 2008 16:51 CEST]
Abstract: This review focuses on the stability of voltammetric signals recorded overperiods of months with carbon paste electrodes (CPEs) implanted in the brain. The keyinteraction underlying this stability is between the pasting oil and brain lipids that arecapable of inhibiting the fouling caused by proteins. In brain regions receiving a significantdopaminergic input, a peak due to the methylated metabolites of dopamine, principallyhomovanillic acid (HVA), is clearly resolved using slow sweep voltammetry. Although anumber of factors limit the time resolution for monitoring brain HVA concentrationdynamics, the stability of CPEs allows investigations of long-term effects of drugs, as wellas behavioral studies, not possible using other in-vivo monitoring techniques.
Keywords: in-vivo voltammetry; homovanillic acid; HVA; ascorbic acid; uric acid; diurnal changes; haloperidol; apomorphine; dopamine release; motor activity; benzodiazepines; food; review.
Article Statistics
Click here to load and display the download statistics.Cite This Article
MDPI and ACS Style
O’Neill, R.D. Long-Term Monitoring of Brain Dopamine Metabolism In Vivo with Carbon Paste Electrodes. Sensors 2005, 5, 317-342.
AMA StyleO’Neill RD. Long-Term Monitoring of Brain Dopamine Metabolism In Vivo with Carbon Paste Electrodes. Sensors. 2005; 5(6):317-342.
Chicago/Turabian StyleO’Neill, Robert D. 2005. "Long-Term Monitoring of Brain Dopamine Metabolism In Vivo with Carbon Paste Electrodes." Sensors 5, no. 6: 317-342.