Next Article in Journal
3D Analysis of Upper Limbs Motion during Rehabilitation Exercises Using the KinectTM Sensor: Development, Laboratory Validation and Clinical Application
Previous Article in Journal
An Adaptive Nonlocal Mean Filter for PolSAR Data with Shape-Adaptive Patches Matching
Article Menu
Issue 7 (July) cover image

Export Article

Open AccessArticle
Sensors 2018, 18(7), 2214; https://doi.org/10.3390/s18072214

Direct Detection of Candida albicans with a Membrane Based Electrochemical Impedance Spectroscopy Sensor

1
Department of Micro- and Nanotechnology, Technical University of Denmark, rsteds Plads, Building 345 B, 2800 Kgs. Lyngby, Denmark
2
Department of Haematology, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark
*
Author to whom correspondence should be addressed.
Received: 24 May 2018 / Revised: 25 June 2018 / Accepted: 6 July 2018 / Published: 10 July 2018
(This article belongs to the Section Biosensors)
Full-Text   |   PDF [5249 KB, uploaded 10 July 2018]   |  

Abstract

Candidemia and invasive candidiasis is a cause of high mortality and morbidity rates among hospitalized patients worldwide. The occurrence of the infections increases due to the complexity of the patients and overuse of the antifungal therapy. The current Candida detection method includes blood culturing which is a lengthy procedure and thus delays the administration of the antifungal therapy. Even though the results are available after 48 h it is still the gold standard in pathogen detection in a hospital setting. In this work we present an electrochemical impedance sensor that is capable of detecting Candida albicans yeast. The yeast cells are captured on electrodes specifically functionalized with anti-Candida antibodies and detection is achieved by electrochemical impedance spectroscopy. The sensor allows for detection of the yeast cells at clinically relevant concentrations in less than 1 h. View Full-Text
Keywords: Candida; electrochemical impedance spectroscopy; membrane based sensor Candida; electrochemical impedance spectroscopy; membrane based sensor
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Kwasny, D.; Tehrani, S.E.; Almeida, C.; Schjødt, I.; Dimaki, M.; Svendsen, W.E. Direct Detection of Candida albicans with a Membrane Based Electrochemical Impedance Spectroscopy Sensor. Sensors 2018, 18, 2214.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top