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Sensors 2017, 17(4), 861; doi:10.3390/s17040861

Electrochemical Detection of Dopamine Using 3D Porous Graphene Oxide/Gold Nanoparticle Composites

1
School of Integrative Engineering, Chung-Ang University, Seoul 06974, Korea
2
Department of Chemical and Biomolecular Engineering, Sogang University, Seoul 04109, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editors: Nathan Lindquist, Nathan Wittenberg and Sang-Hyun Oh
Received: 2 March 2017 / Revised: 6 April 2017 / Accepted: 11 April 2017 / Published: 14 April 2017
(This article belongs to the Special Issue Micro and Nanofabrication Technologies for Biosensors)
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Abstract

The detection of dopamine in a highly sensitive and selective manner is crucial for the early diagnosis of a number of neurological diseases/disorders. Here, a report on a new platform for the electrochemical detection of dopamine with a considerable accuracy that comprises a 3D porous graphene oxide (pGO)/gold nanoparticle (GNP)/pGO composite-modified indium tin oxide (ITO) is presented. The pGO was first synthesized and purified by ultrasonication and centrifugation, and it was then further functionalized on the surface of a GNP-immobilized ITO electrode. Remarkably, owing to the synergistic effects of the pGO and GNPs, the 3D pGO-GNP-pGO-modified ITO electrode showed a superior dopamine-detection performance compared with the other pGO- or GNP-modified ITO electrodes. The linear range of the newly developed sensing platform is from 0.1 μM to 30 μM with a limit of detection (LOD) of 1.28 μM, which is more precise than the other previously reported GO-functionalized electrodes. Moreover, the 3D pGO-GNP-pGO-modified ITO electrodes maintained their detection capability even in the presence of several interfering molecules (e.g., ascorbic acid, glucose). The proposed platform of the 3D pGO-GNP-pGO-modified ITO electrode could therefore serve as a competent candidate for the development of a dopamine-sensing platform that is potentially applicable for the early diagnosis of various neurological diseases/disorders. View Full-Text
Keywords: graphene oxide; porous structure; gold nanoparticles; indium tin oxide; neurotransmitters; dopamine; composites; electrochemical detection graphene oxide; porous structure; gold nanoparticles; indium tin oxide; neurotransmitters; dopamine; composites; electrochemical detection
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Choo, S.-S.; Kang, E.-S.; Song, I.; Lee, D.; Choi, J.-W.; Kim, T.-H. Electrochemical Detection of Dopamine Using 3D Porous Graphene Oxide/Gold Nanoparticle Composites. Sensors 2017, 17, 861.

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