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Sensors 2017, 17(5), 1053; doi:10.3390/s17051053

Characterizing Esophageal Cancerous Cells at Different Stages Using the Dielectrophoretic Impedance Measurement Method in a Microchip

1
Graduate Institute of Opto-Mechatronics, National Chung Cheng University, Chia-Yi 621, Taiwan
2
Department of Mechanical Engineering, National Chung Cheng University, Chia-Yi 621, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editors: Nathan Lindquist, Nathan Wittenberg and Sang-Hyun Oh
Received: 29 March 2017 / Revised: 28 April 2017 / Accepted: 4 May 2017 / Published: 6 May 2017
(This article belongs to the Special Issue Micro and Nanofabrication Technologies for Biosensors)
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Abstract

Analysis of cancerous cells allows us to provide useful information for the early diagnosis of cancer and to monitor treatment progress. An approach based on electrical principles has recently become an attractive technique. This study presents a microdevice that utilizes a dielectrophoretic impedance measurement method for the identification of cancerous cells. The proposed biochip consists of circle-on-line microelectrodes that are patterned using a standard microfabrication processes. A sample of various cell concentrations was introduced in an open-top microchamber. The target cells were collectively concentrated between the microelectrodes using dielectrophoresis manipulation, and their electrical impedance properties were also measured. Different stages of human esophageal squamous cell carcinoma lines could be distinguished. This result is consistent with findings using hyperspectral imaging technology. Moreover, it was observed that the distinguishing characteristics change in response to the progression of cancer cell invasiveness by Raman spectroscopy. The device enables highly efficient cell collection and provides rapid, sensitive, and label-free electrical measurements of cancerous cells. View Full-Text
Keywords: dielectrophoretic impedance measurement (DEPIM); esophageal cancer; cytological stage; admittance dielectrophoretic impedance measurement (DEPIM); esophageal cancer; cytological stage; admittance
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MDPI and ACS Style

Wang, H.-C.; Nguyen, N.-V.; Lin, R.-Y.; Jen, C.-P. Characterizing Esophageal Cancerous Cells at Different Stages Using the Dielectrophoretic Impedance Measurement Method in a Microchip. Sensors 2017, 17, 1053.

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