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Sensors 2017, 17(2), 383; doi:10.3390/s17020383

Electrochemical Oxidation of l-selenomethionine and Se-methylseleno-l-cysteine at a Thiol-Compound-Modified Gold Electrode: Its Application in a Flow-Through Voltammetric Sensor

Department of Medical Chemistry, Chia Nan University of Pharmacy and Science, 60 Erh-Jen Road, Section 1, Rende, Tainan 71743, Taiwan
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Author to whom correspondence should be addressed.
Academic Editor: W. Rudolf Seitz
Received: 28 December 2016 / Revised: 8 February 2017 / Accepted: 14 February 2017 / Published: 16 February 2017
(This article belongs to the Section Chemical Sensors)
View Full-Text   |   Download PDF [1268 KB, uploaded 17 February 2017]   |  

Abstract

A flow-electrolytic cell that consists of a bare gold wire or of different thiol-compound-modified gold electrodes (such as 2,4-thiazolidinedione, 2-mercapto-5-thiazoline, 2-mercaptothiazoline, l-cysteine, thioglycolic acid) was designed to be used in a voltammetric detector to identify l-selenomethionine and Se-methylseleno-l-cysteine using high-performance liquid chromatography. Both l-selenomethionine and Se-methylseleno-l-cysteine are more efficiently electrochemically oxidized on a thiol/gold than on a bare gold electrode. For the DC mode, and for measurements with suitable experimental parameters, a linear concentration from 10 to 1600 ng·mL−1 was found. The limits of quantification for l-selenomethionine and Se-methylseleno-l-cysteine were below 10 ng·mL−1. The method can be applied to the quantitative determination of l-selenomethionine and Se-methylseleno-l-cysteine in commercial selenium-containing supplement products. Findings using high-performance liquid chromatography with a flow-through voltammetric detector and ultraviolet detector are comparable. View Full-Text
Keywords: thiol-modified gold electrodes; amperometric detection; l-selenomethionine; Se-methylseleno-l-cysteine thiol-modified gold electrodes; amperometric detection; l-selenomethionine; Se-methylseleno-l-cysteine
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Wang, L.-H.; Zhang, Y.-H. Electrochemical Oxidation of l-selenomethionine and Se-methylseleno-l-cysteine at a Thiol-Compound-Modified Gold Electrode: Its Application in a Flow-Through Voltammetric Sensor. Sensors 2017, 17, 383.

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