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Sensors 2017, 17(12), 2733; https://doi.org/10.3390/s17122733

Pre-Clinical Tests of an Integrated CMOS Biomolecular Sensor for Cardiac Diseases Diagnosis

1
Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei 10617, Taiwan
2
Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei 10048, Taiwan
3
Telehealth Center, National Taiwan University Hospital, Taipei 10048, Taiwan
4
Department of Laboratory Medicine, National Taiwan University Hospital, Taipei 10048, Taiwan
5
Graduate Institute of Electronics Engineering, National Taiwan University, Taipei 10617, Taiwan
6
Department of Materials Engineering, Ming Chi University of Technology, New Taipei 24301, Taiwan
7
Insisute of Biophotonics, National Yang-Ming University, Taipei 11221, Taiwan
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 26 October 2017 / Revised: 22 November 2017 / Accepted: 24 November 2017 / Published: 26 November 2017
(This article belongs to the Special Issue Sensors for Health Monitoring and Disease Diagnosis)
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Abstract

Coronary artery disease and its related complications pose great threats to human health. In this work, we aim to clinically evaluate a CMOS field-effect biomolecular sensor for cardiac biomarkers, cardiac-specific troponin-I (cTnI), N-terminal prohormone brain natriuretic peptide (NT-proBNP), and interleukin-6 (IL-6). The CMOS biosensor is implemented via a standard commercialized 0.35 μm CMOS process. To validate the sensing characteristics, in buffer conditions, the developed CMOS biosensor has identified the detection limits of IL-6, cTnI, and NT-proBNP as being 45 pM, 32 pM, and 32 pM, respectively. In clinical serum conditions, furthermore, the developed CMOS biosensor performs a good correlation with an enzyme-linked immuno-sorbent assay (ELISA) obtained from a hospital central laboratory. Based on this work, the CMOS field-effect biosensor poses good potential for accomplishing the needs of a point-of-care testing (POCT) system for heart disease diagnosis. View Full-Text
Keywords: CMOS biosensor; field-effect biosensor; heart disease; troponin-I; N-terminal prohormone brain natriuretic peptide; interleukin-6 CMOS biosensor; field-effect biosensor; heart disease; troponin-I; N-terminal prohormone brain natriuretic peptide; interleukin-6
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Lee, J.-K.; Wang, I.-S.; Huang, C.-H.; Chen, Y.-F.; Huang, N.-T.; Lin, C.-T. Pre-Clinical Tests of an Integrated CMOS Biomolecular Sensor for Cardiac Diseases Diagnosis. Sensors 2017, 17, 2733.

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