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Sensors 2017, 17(11), 2495; doi:10.3390/s17112495

The Evaluation of a Low-Cost Colorimeter for Glucose Detection in Salivary Samples

1
CONACyT-CIMAV S.C., 31136 Chihuahua, Mexico
2
Department of Engineering and Chemistry of Materials, CIMAV S.C., 31136 Chihuahua, Mexico
3
CIMAV S.C., Ejido Arroyo Seco, 34147 Durango, Mexico
*
Author to whom correspondence should be addressed.
Received: 4 September 2017 / Revised: 26 September 2017 / Accepted: 4 October 2017 / Published: 1 November 2017
(This article belongs to the Section Chemical Sensors)
View Full-Text   |   Download PDF [3718 KB, uploaded 1 November 2017]   |  

Abstract

Given the limited access to healthcare resources, low-income settings require the development of affordable technology. Here we present the design and evaluation of a low-cost colorimeter applied to the non-invasive monitoring of Diabetes Mellitus through the detection of glucose in salival fluid. Samples were processed by the glucose oxidase-peroxidase enzymatic system and analyzed with the development equipment. A light emission diode of 532.5 nm was used as an excitation source and a RGB module was used as a receptor. A calibration curve to quantify the concentration of salivary glucose (0 to 18 mg/dL) was carried out by relating the RGB components registered with glucose concentrations, achieving a limit of detection of 0.17 mg/dL with a CV of 5% (n = 3). Salivary samples of diabetic and healthy volunteers were processed with the equipment showing an average concentration of 1.5519 ± 0.4511 mg/dL for the first and 4.0479 ± 1.6103 mg/dL for the last, allowing a discrimination between both groups. Results were validated against a UV-Vis-NIR spectrophotometer with a correspondence of R2 of 0.98194 between both instruments. Results suggest the potential application of the developed device to the sensitive detection of relevant analytes with a low-cost, user-friendly, low-power and portable instrumentation. View Full-Text
Keywords: saliva; low-cost; RGB; Diabetes Mellitus; non-invasive saliva; low-cost; RGB; Diabetes Mellitus; non-invasive
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Dominguez, R.B.; Orozco, M.A.; Chávez, G.; Márquez-Lucero, A. The Evaluation of a Low-Cost Colorimeter for Glucose Detection in Salivary Samples. Sensors 2017, 17, 2495.

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