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Sensors 2017, 17(1), 90; doi:10.3390/s17010090

Wavelength-Scanning SPR Imaging Sensors Based on an Acousto-Optic Tunable Filter and a White Light Laser

1
College of Optoelectronic Engineering, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Shenzhen Key Laboratory of Sensor Technology, Shenzhen University, Shenzhen 518060, China
2
Department of Electronic Engineering, The Chinese University of Hong Kong, Shatin 999077, Hong Kong, China
3
Shenzhen Entry-exit Inspection and Quarantine Bureau, Shenzhen 518033, China
4
Department of Bioengineering and COMSET, Clemson University, Clemson, SC 29634, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Laura M. Lechuga
Received: 13 November 2016 / Revised: 20 December 2016 / Accepted: 1 January 2017 / Published: 5 January 2017
(This article belongs to the Special Issue Last Advances in Nanoplasmonics Biosensors)
View Full-Text   |   Download PDF [2058 KB, uploaded 5 January 2017]   |  

Abstract

A fast surface plasmon resonance (SPR) imaging biosensor system based on wavelength interrogation using an acousto-optic tunable filter (AOTF) and a white light laser is presented. The system combines the merits of a wide-dynamic detection range and high sensitivity offered by the spectral approach with multiplexed high-throughput data collection and a two-dimensional (2D) biosensor array. The key feature is the use of AOTF to realize wavelength scan from a white laser source and thus to achieve fast tracking of the SPR dip movement caused by target molecules binding to the sensor surface. Experimental results show that the system is capable of completing a SPR dip measurement within 0.35 s. To the best of our knowledge, this is the fastest time ever reported in the literature for imaging spectral interrogation. Based on a spectral window with a width of approximately 100 nm, a dynamic detection range and resolution of 4.63 × 10−2 refractive index unit (RIU) and 1.27 × 10−6 RIU achieved in a 2D-array sensor is reported here. The spectral SPR imaging sensor scheme has the capability of performing fast high-throughput detection of biomolecular interactions from 2D sensor arrays. The design has no mechanical moving parts, thus making the scheme completely solid-state. View Full-Text
Keywords: surface plasmon resonance; SPR imaging; microarray analysis; wavelength scanning; acousto-optic tunable filter (AOTF); white light laser surface plasmon resonance; SPR imaging; microarray analysis; wavelength scanning; acousto-optic tunable filter (AOTF); white light laser
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Zeng, Y.; Wang, L.; Wu, S.-Y.; He, J.; Qu, J.; Li, X.; Ho, H.-P.; Gu, D.; Gao, B.Z.; Shao, Y. Wavelength-Scanning SPR Imaging Sensors Based on an Acousto-Optic Tunable Filter and a White Light Laser. Sensors 2017, 17, 90.

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