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Sensors 2016, 16(9), 1418; doi:10.3390/s16091418

A Disposable Microfluidic Device with a Screen Printed Electrode for Mimicking Phase II Metabolism

1
Department of Chemistry, University of Hull, Cottingham Road, Hull HU6 7RX, UK
2
Department of Engineering, University of Hull, Cottingham Road, Hull HU6 7RX, UK
*
Author to whom correspondence should be addressed.
Academic Editors: Jesus Iniesta Valcarcel and Craig E. Banks
Received: 9 May 2016 / Revised: 23 August 2016 / Accepted: 25 August 2016 / Published: 2 September 2016
(This article belongs to the Special Issue Recent Advances in Biosensors Based Screen Printed Platforms)
View Full-Text   |   Download PDF [4125 KB, uploaded 2 September 2016]   |  

Abstract

Human metabolism is investigated using several in vitro methods. However, the current methodologies are often expensive, tedious and complicated. Over the last decade, the combination of electrochemistry (EC) with mass spectrometry (MS) has a simpler and a cheaper alternative to mimic the human metabolism. This paper describes the development of a disposable microfluidic device with a screen-printed electrode (SPE) for monitoring phase II GSH reactions. The proposed chip has the potential to be used as a primary screening tool, thus complementing the current in vitro methods. View Full-Text
Keywords: metabolism; electrochemistry; screen-printed electrodes; mass spectrometry metabolism; electrochemistry; screen-printed electrodes; mass spectrometry
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MDPI and ACS Style

Vasiliadou, R.; Nasr Esfahani, M.M.; Brown, N.J.; Welham, K.J. A Disposable Microfluidic Device with a Screen Printed Electrode for Mimicking Phase II Metabolism. Sensors 2016, 16, 1418.

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