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Sensors 2015, 15(8), 17916-17925; doi:10.3390/s150817916

Selective Surface Acoustic Wave-Based Organophosphorus Sensor Employing a Host-Guest Self-Assembly Monolayer of β-Cyclodextrin Derivative

1,* , 1,†
State Key Laboratory of NBC Protection for Civilian, Yangfang, Changping District, Beijing 102205, China
Institute of Acoustic, Chinese Academy of Science, Zhongguancun Street, Haidian District, Beijing 100080, China
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Vittorio M.N. Passaro
Received: 20 May 2015 / Revised: 2 July 2015 / Accepted: 20 July 2015 / Published: 23 July 2015
(This article belongs to the Special Issue Integrated Intelligent Sensory Systems with Self-x Capabilities)
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Self-assembly and molecular imprinting technologies are very attractive technologies for the development of artificial recognition systems and provide chemical recognition based on need and not happenstance. In this paper, we employed a b-cyclodextrin derivative surface acoustic wave (SAW) chemical sensor for detecting the chemical warfare agents (CWAs) sarin (O-Isoprophyl methylphosphonofluoridate, GB). Using sarin acid (isoprophyl hydrogen methylphosphonate) as an imprinting template, mono[6-deoxy-6-[(mercaptodecamethylene)thio]]-β-cyclodextrin was prepared by self-assembled method on one of the SAW oscillators. After templates’ removal, a sensitive and selective molecular imprinting (MIP) monolayer for GB was prepared. Electrochemical impedance spectroscopy and atomic force microscope (AFM) were used to characterize this film. Comparing the detection results to GB by MIP film and non-MIP film, the molecularly imprinting effect was also proved. The resulting SAW sensor could detect sarin as low as 0.10 mg/m3 at room temperature and the frequency shift was about 300 Hz. The response frequency increased linearly with increasing sarin concentration in the range of 0.7 mg/m3~3.0 mg/m3. When sarin was detected under different temperatures, the SAW sensor exhibited outstanding sensitivity and reliability. View Full-Text
Keywords: surface acoustic wave (SAW); b-cyclodextrin; self-assembly; molecular imprinting (MIP); detection surface acoustic wave (SAW); b-cyclodextrin; self-assembly; molecular imprinting (MIP); detection

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Pan, Y.; Mu, N.; Shao, S.; Yang, L.; Wang, W.; Xie, X.; He, S. Selective Surface Acoustic Wave-Based Organophosphorus Sensor Employing a Host-Guest Self-Assembly Monolayer of β-Cyclodextrin Derivative. Sensors 2015, 15, 17916-17925.

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