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Sensors 2015, 15(7), 16281-16313; doi:10.3390/s150716281

Nucleic Acid Aptamers: An Emerging Tool for Biotechnology and Biomedical Sensing

1
Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA 92093-0407, USA
2
Materials Science and Engineering Program, University of California San Diego, La Jolla, CA 92093-0418, USA
3
College of Basic Medicine and Forensic Medicine, Sichuan University, Chengdu 610041, China
4
College of Manufacturing Science and Engineering, Sichuan University, Chengdu 610041, China
5
Department of Bioengineering, University of California San Diego, La Jolla, CA 92093-0412, USA
6
Chemical Engineering Program, University of California San Diego, La Jolla, CA 92093-0448, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Yeshaiahu Fainman
Received: 25 April 2015 / Revised: 26 June 2015 / Accepted: 30 June 2015 / Published: 6 July 2015
(This article belongs to the Special Issue Resonant Sensors and Sensor Fusion)
View Full-Text   |   Download PDF [2089 KB, uploaded 6 July 2015]   |  

Abstract

Detection of small molecules or proteins of living cells provides an exceptional opportunity to study genetic variations and functions, cellular behaviors, and various diseases including cancer and microbial infections. Our aim in this review is to give an overview of selected research activities related to nucleic acid-based aptamer techniques that have been reported in the past two decades. Limitations of aptamers and possible approaches to overcome these limitations are also discussed. View Full-Text
Keywords: DNA; RNA; aptamer; SELEX; biomarkers; polymer; liposome DNA; RNA; aptamer; SELEX; biomarkers; polymer; liposome
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ku, T.-H.; Zhang, T.; Luo, H.; Yen, T.M.; Chen, P.-W.; Han, Y.; Lo, Y.-H. Nucleic Acid Aptamers: An Emerging Tool for Biotechnology and Biomedical Sensing. Sensors 2015, 15, 16281-16313.

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