Next Article in Journal
UAV Deployment Exercise for Mapping Purposes: Evaluation of Emergency Response Applications
Next Article in Special Issue
Nucleic Acid Aptamers: An Emerging Tool for Biotechnology and Biomedical Sensing
Previous Article in Journal
New Hybrid Algorithms for Estimating Tree Stem Diameters at Breast Height Using a Two Dimensional Terrestrial Laser Scanner
Previous Article in Special Issue
Surface Plasmon Resonance: A Versatile Technique for Biosensor Applications
Article Menu

Export Article

Open AccessReview
Sensors 2015, 15(7), 15684-15716; doi:10.3390/s150715684

Localized Surface Plasmon Resonance Biosensing: Current Challenges and Approaches

Department of Chemistry, College of Arts and Sciences, University of Cincinnati, 301 West Clifton Court, Cincinnati, OH 45221-0172, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Yeshaiahu Fainman
Received: 17 April 2015 / Revised: 13 June 2015 / Accepted: 23 June 2015 / Published: 2 July 2015
(This article belongs to the Special Issue Resonant Sensors and Sensor Fusion)
View Full-Text   |   Download PDF [2977 KB, uploaded 2 July 2015]   |  

Abstract

Localized surface plasmon resonance (LSPR) has emerged as a leader among label-free biosensing techniques in that it offers sensitive, robust, and facile detection. Traditional LSPR-based biosensing utilizes the sensitivity of the plasmon frequency to changes in local index of refraction at the nanoparticle surface. Although surface plasmon resonance technologies are now widely used to measure biomolecular interactions, several challenges remain. In this article, we have categorized these challenges into four categories: improving sensitivity and limit of detection, selectivity in complex biological solutions, sensitive detection of membrane-associated species, and the adaptation of sensing elements for point-of-care diagnostic devices. The first section of this article will involve a conceptual discussion of surface plasmon resonance and the factors affecting changes in optical signal detected. The following sections will discuss applications of LSPR biosensing with an emphasis on recent advances and approaches to overcome the four limitations mentioned above. First, improvements in limit of detection through various amplification strategies will be highlighted. The second section will involve advances to improve selectivity in complex media through self-assembled monolayers, “plasmon ruler” devices involving plasmonic coupling, and shape complementarity on the nanoparticle surface. The following section will describe various LSPR platforms designed for the sensitive detection of membrane-associated species. Finally, recent advances towards multiplexed and microfluidic LSPR-based devices for inexpensive, rapid, point-of-care diagnostics will be discussed. View Full-Text
Keywords: plasmonic; biosensing; noble metal nanoparticles; point-of-care diagnostics plasmonic; biosensing; noble metal nanoparticles; point-of-care diagnostics
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Unser, S.; Bruzas, I.; He, J.; Sagle, L. Localized Surface Plasmon Resonance Biosensing: Current Challenges and Approaches. Sensors 2015, 15, 15684-15716.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top