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Sensors 2015, 15(5), 9815-9826; doi:10.3390/s150509815

A PDMS-Based 2-Axis Waterproof Scanner for Photoacoustic Microscopy

1
Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Korea
2
Department of Creative IT Engineering, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Korea
3
School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Korea
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Stefano Mariani
Received: 22 March 2015 / Revised: 20 April 2015 / Accepted: 20 April 2015 / Published: 27 April 2015
(This article belongs to the Special Issue Modeling, Testing and Reliability Issues in MEMS Engineering)
View Full-Text   |   Download PDF [3680 KB, uploaded 27 April 2015]   |  

Abstract

Optical-resolution photoacoustic microscopy (OR-PAM) is an imaging tool to provide in vivo optically sensitive images in biomedical research. To achieve a small size, fast imaging speed, wide scan range, and high signal-to-noise ratios (SNRs) in a water environment, we introduce a polydimethylsiloxane (PDMS)-based 2-axis scanner for a flexible and waterproof structure. The design, theoretical background, fabrication process and performance of the scanner are explained in details. The designed and fabricated scanner has dimensions of 15 × 15 × 15 mm along the X, Y and Z axes, respectively. The characteristics of the scanner are tested under DC and AC conditions. By pairing with electromagnetic forces, the maximum scanning angles in air and water are 18° and 13° along the X and Y axes, respectively. The measured resonance frequencies in air and water are 60 and 45 Hz along the X axis and 45 and 30 Hz along the Y axis, respectively. Finally, OR-PAM with high SNRs is demonstrated using the fabricated scanner, and the PA images of micro-patterned samples and microvasculatures of a mouse ear are successfully obtained with high-resolution and wide-field of view. OR-PAM equipped with the 2-axis PDMS based waterproof scanner has lateral and axial resolutions of 3.6 μm and 26 μm, respectively. This compact OR-PAM system could potentially and widely be used in preclinical and clinical applications. View Full-Text
Keywords: optical-resolution photoacoustic microscopy; MEMS scanner; polydimethylsiloxane optical-resolution photoacoustic microscopy; MEMS scanner; polydimethylsiloxane
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Kim, J.Y.; Lee, C.; Park, K.; Lim, G.; Kim, C. A PDMS-Based 2-Axis Waterproof Scanner for Photoacoustic Microscopy. Sensors 2015, 15, 9815-9826.

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