Label-Free, Single Molecule Resonant Cavity Detection: A Double-Blind Experimental Study
AbstractOptical resonant cavity sensors are gaining increasing interest as a potential diagnostic method for a range of applications, including medical prognostics and environmental monitoring. However, the majority of detection demonstrations to date have involved identifying a “known” analyte, and the more rigorous double-blind experiment, in which the experimenter must identify unknown solutions, has yet to be performed. This scenario is more representative of a real-world situation. Therefore, before these devices can truly transition, it is necessary to demonstrate this level of robustness. By combining a recently developed surface chemistry with integrated silica optical sensors, we have performed a double-blind experiment to identify four unknown solutions. The four unknown solutions represented a subset or complete set of four known solutions; as such, there were 256 possible combinations. Based on the single molecule detection signal, we correctly identified all solutions. In addition, as part of this work, we developed noise reduction algorithms. View Full-Text
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Chistiakova, M.V.; Shi, C.; Armani, A.M. Label-Free, Single Molecule Resonant Cavity Detection: A Double-Blind Experimental Study. Sensors 2015, 15, 6324-6341.
Chistiakova MV, Shi C, Armani AM. Label-Free, Single Molecule Resonant Cavity Detection: A Double-Blind Experimental Study. Sensors. 2015; 15(3):6324-6341.Chicago/Turabian Style
Chistiakova, Maria V.; Shi, Ce; Armani, Andrea M. 2015. "Label-Free, Single Molecule Resonant Cavity Detection: A Double-Blind Experimental Study." Sensors 15, no. 3: 6324-6341.