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Sensors 2014, 14(9), 16196-16211; doi:10.3390/s140916196

Experimental Tools to Study Molecular Recognition within the Nanoparticle Corona

Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave. Cambridge, MA 02139, USA
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Received: 1 July 2014 / Revised: 15 August 2014 / Accepted: 18 August 2014 / Published: 2 September 2014
(This article belongs to the Special Issue Molecular Sensing and Molecular Electronics)
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Abstract

Advancements in optical nanosensor development have enabled the design of sensors using synthetic molecular recognition elements through a recently developed method called Corona Phase Molecular Recognition (CoPhMoRe). The synthetic sensors resulting from these design principles are highly selective for specific analytes, and demonstrate remarkable stability for use under a variety of conditions. An essential element of nanosensor development hinges on the ability to understand the interface between nanoparticles and the associated corona phase surrounding the nanosensor, an environment outside of the range of traditional characterization tools, such as NMR. This review discusses the need for new strategies and instrumentation to study the nanoparticle corona, operating in both in vitro and in vivo environments. Approaches to instrumentation must have the capacity to concurrently monitor nanosensor operation and the molecular changes in the corona phase. A detailed overview of new tools for the understanding of CoPhMoRe mechanisms is provided for future applications. View Full-Text
Keywords: optical sensors; molecular recognition; fluorescence; single-molecule microscopy; neurotransmitters; corona phase; carbon nanotubes optical sensors; molecular recognition; fluorescence; single-molecule microscopy; neurotransmitters; corona phase; carbon nanotubes
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Landry, M.P.; Kruss, S.; Nelson, J.T.; Bisker, G.; Iverson, N.M.; Reuel, N.F.; Strano, M.S. Experimental Tools to Study Molecular Recognition within the Nanoparticle Corona. Sensors 2014, 14, 16196-16211.

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