Next Article in Journal
Techniques for Clutter Suppression in the Presence of Body Movements during the Detection of Respiratory Activity through UWB Radars
Next Article in Special Issue
Laccase Biosensor Based on Electrospun Copper/Carbon Composite Nanofibers for Catechol Detection
Previous Article in Journal
Seeing by Touch: Evaluation of a Soft Biologically-Inspired Artificial Fingertip in Real-Time Active Touch
Article Menu

Export Article

Open AccessArticle
Sensors 2014, 14(2), 2578-2594; doi:10.3390/s140202578

Computational Modeling of Mediator Oxidation by Oxygen in an Amperometric Glucose Biosensor

1
Faculty of Mathematics and Informatics, Vilnius University, Didlaukio 47, LT-08303 Vilnius, Lithuania
2
Institute of Biochemistry, Vilnius University, Mokslininku 12, LT-08662 Vilnius, Lithuania
*
Author to whom correspondence should be addressed.
Received: 10 December 2013 / Revised: 26 January 2014 / Accepted: 27 January 2014 / Published: 7 February 2014
(This article belongs to the Special Issue Amperometric Biosensors)
View Full-Text   |   Download PDF [369 KB, uploaded 21 June 2014]   |  

Abstract

In this paper, an amperometric glucose biosensor is modeled numerically. The model is based on non-stationary reaction-diffusion type equations. The model consists of four layers. An enzyme layer lies directly on a working electrode surface. The enzyme layer is attached to an electrode by a polyvinyl alcohol (PVA) coated terylene membrane. This membrane is modeled as a PVA layer and a terylene layer, which have different diffusivities. The fourth layer of the model is the diffusion layer, which is modeled using the Nernst approach. The system of partial differential equations is solved numerically using the finite difference technique. The operation of the biosensor was analyzed computationally with special emphasis on the biosensor response sensitivity to oxygen when the experiment was carried out in aerobic conditions. Particularly, numerical experiments show that the overall biosensor response sensitivity to oxygen is insignificant. The simulation results qualitatively explain and confirm the experimentally observed biosensor behavior. View Full-Text
Keywords: modeling; reaction-diffusion; biosensor; oxygen; aerobic; anaerobic modeling; reaction-diffusion; biosensor; oxygen; aerobic; anaerobic
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Šimelevičius, D.; Petrauskas, K.; Baronas, R.; Razumienė, J. Computational Modeling of Mediator Oxidation by Oxygen in an Amperometric Glucose Biosensor. Sensors 2014, 14, 2578-2594.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top