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Sensors 2014, 14(11), 20602-20619; doi:10.3390/s141120602

CMOS Time-Resolved, Contact, and Multispectral Fluorescence Imaging for DNA Molecular Diagnostics

Department of Physics and Materials Science, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong
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Received: 14 July 2014 / Revised: 11 September 2014 / Accepted: 27 October 2014 / Published: 31 October 2014
(This article belongs to the Special Issue Molecular Sensing and Molecular Electronics)
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Abstract

Instrumental limitations such as bulkiness and high cost prevent the fluorescence technique from becoming ubiquitous for point-of-care deoxyribonucleic acid (DNA) detection and other in-field molecular diagnostics applications. The complimentary metal-oxide-semiconductor (CMOS) technology, as benefited from process scaling, provides several advanced capabilities such as high integration density, high-resolution signal processing, and low power consumption, enabling sensitive, integrated, and low-cost fluorescence analytical platforms. In this paper, CMOS time-resolved, contact, and multispectral imaging are reviewed. Recently reported CMOS fluorescence analysis microsystem prototypes are surveyed to highlight the present state of the art. View Full-Text
Keywords: CMOS; FRET; lab-on-a-chip; microsystem; fluorescence spectroscopy; multispectral imaging; contact imaging; quantum dots; DNA analysis; point-of-care; medical diagnostics; time-resolved; TCSPC CMOS; FRET; lab-on-a-chip; microsystem; fluorescence spectroscopy; multispectral imaging; contact imaging; quantum dots; DNA analysis; point-of-care; medical diagnostics; time-resolved; TCSPC
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Guo, N.; Cheung, K.W.; Wong, H.T.; Ho, D. CMOS Time-Resolved, Contact, and Multispectral Fluorescence Imaging for DNA Molecular Diagnostics. Sensors 2014, 14, 20602-20619.

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